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Degradation of furazolidone by bacteria Acinetobacter calcoaceticus T32, Pseudomonas putida SP1 and Proteus mirabilis V7

文献类型：期刊论文

作者Zhang, Weiwei1,2; Niu, Zongliang1,2; Yin, Kun1,2,3; Liu, Feng4; Chen, Lingxin1,2
刊名INTERNATIONAL BIODETERIORATION & BIODEGRADATION
出版日期2013-02-01
卷号77页码:45-50
关键词Furazolidone Bacterial Strain Degradation Glutathione-s-transferase (Gst) Cytotoxicity
ISSN号0964-8305
产权排序[Zhang, Weiwei; Niu, Zongliang; Yin, Kun; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Zhang, Weiwei; Niu, Zongliang; Yin, Kun; Chen, Lingxin] YICCAS, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Shandong, Peoples R China; [Yin, Kun] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China; [Liu, Feng] China Agr Univ Yantai, Dept Aquaculture, Yantai 264670, Peoples R China
通讯作者Chen, LX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, 17 Chunhui Rd, Yantai 264003, Peoples R China. wwzhang@yic.ac.cn ; nzl5423@163.com ; hanmiltion@163.com ; liufeng0324@hotmail.com ; lxchen@yic.ac.cn
文献子类Article
英文摘要Furazolidone (FZD) has been widely used as an antibacterial and antiprotozoal feed additive for poultry, cattle and farmed fish. Since FZD has been shown to have mutagenic, genotoxic and potentially carcinogenic properties when tested in a variety of systems, there is an increasing need to find a way to remove FZD from contaminated environments. In this report, three bacterial strains Acinetobacter calcoaceticus 132, Pseudomonas putida SP1 and Proteus mirabilis V7 capable of degrading FZD effectively were isolated, identified and characterized. The reduced FZD. concentration after degradation was determined by HPLC. After bacterial cells were grown in the media containing 5 mg l(-1) FZD for 5 days, almost all FZD was degraded by A. calcoaceticus T32, and more than 50% of FZD was degraded by P. putida SP1 and P. mirabilis V7, respectively. Bacterial GST activity of A. calcoaceticus T32, P. putida SP1 and P. mirabilis V7 was determined to be influenced by different FZD concentrations. Cytotoxicity analysis showed that FZD was degraded to the metabolites with far less cytotoxicity compared to FZD. The inoculation of bacterial strains A. calcoaceticus T32, P. putida SP1 and P. mirabilis V7 into FZD-contained media resulted in a higher degradation efficiency than natural degradation, which indicated the potential application of these strains in treatment of FZD-polluted freshwater or seawater environments. (C) 2012 Elsevier Ltd. All rights reserved.; Furazolidone (FZD) has been widely used as an antibacterial and antiprotozoal feed additive for poultry, cattle and farmed fish. Since FZD has been shown to have mutagenic, genotoxic and potentially carcinogenic properties when tested in a variety of systems, there is an increasing need to find a way to remove FZD from contaminated environments. In this report, three bacterial strains Acinetobacter calcoaceticus 132, Pseudomonas putida SP1 and Proteus mirabilis V7 capable of degrading FZD effectively were isolated, identified and characterized. The reduced FZD. concentration after degradation was determined by HPLC. After bacterial cells were grown in the media containing 5 mg l(-1) FZD for 5 days, almost all FZD was degraded by A. calcoaceticus T32, and more than 50% of FZD was degraded by P. putida SP1 and P. mirabilis V7, respectively. Bacterial GST activity of A. calcoaceticus T32, P. putida SP1 and P. mirabilis V7 was determined to be influenced by different FZD concentrations. Cytotoxicity analysis showed that FZD was degraded to the metabolites with far less cytotoxicity compared to FZD. The inoculation of bacterial strains A. calcoaceticus T32, P. putida SP1 and P. mirabilis V7 into FZD-contained media resulted in a higher degradation efficiency than natural degradation, which indicated the potential application of these strains in treatment of FZD-polluted freshwater or seawater environments. (C) 2012 Elsevier Ltd. All rights reserved.
学科主题Biotechnology & Applied Microbiology ; Environmental Sciences
URL标识查看原文
WOS关键词TRANSFERASES ; HPLC ; FATE
WOS研究方向Biotechnology & Applied Microbiology ; Environmental Sciences & Ecology
语种英语
WOS记录号WOS:000316426700007
资助机构Chinese Academy of Sciences [KZCX2-EW-206]; National Natural Science Foundation of China (NSFC) [31200041]; Department of Science and Technology of Shandong Province of China [2008GG20005005]; Department of Science and Technology of Yantai City of China [2010235]; Chinese Academy of Sciences
公开日期2013-08-15
源URL[http://ir.yic.ac.cn/handle/133337/6605]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China
2.YICCAS, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Shandong, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
4.China Agr Univ Yantai, Dept Aquaculture, Yantai 264670, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Weiwei,Niu, Zongliang,Yin, Kun,et al. Degradation of furazolidone by bacteria Acinetobacter calcoaceticus T32, Pseudomonas putida SP1 and Proteus mirabilis V7[J]. INTERNATIONAL BIODETERIORATION & BIODEGRADATION,2013,77:45-50.
APA Zhang, Weiwei,Niu, Zongliang,Yin, Kun,Liu, Feng,&Chen, Lingxin.(2013).Degradation of furazolidone by bacteria Acinetobacter calcoaceticus T32, Pseudomonas putida SP1 and Proteus mirabilis V7.INTERNATIONAL BIODETERIORATION & BIODEGRADATION,77,45-50.
MLA Zhang, Weiwei,et al."Degradation of furazolidone by bacteria Acinetobacter calcoaceticus T32, Pseudomonas putida SP1 and Proteus mirabilis V7".INTERNATIONAL BIODETERIORATION & BIODEGRADATION 77(2013):45-50.

入库方式： OAI收割

来源：烟台海岸带研究所

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