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The influence of salinity on toxicological effects of arsenic in digestive gland of clam Ruditapes philippinarum using metabolomics

文献类型：期刊论文

作者Ji Chenglong1,2,3; Wu Huifeng1,2; Liu Xiaoli1,2,3; Zhao Jianmin1,2; Yu Junbao1,2; Yin Xiuli1,2
刊名CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
出版日期2013-03-01
卷号31期号:2页码:345-352
关键词Ruditapes Philippinarum Salinity Arsenic Toxicological Effects Nuclear Magnetic Resonance (Nmr) Metabolomics
ISSN号0254-4059
产权排序[Ji Chenglong; Wu Huifeng; Liu Xiaoli; Zhao Jianmin; Yu Junbao; Yin Xiuli] Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res YIC, Yantai 264003, Peoples R China; [Ji Chenglong; Wu Huifeng; Liu Xiaoli; Zhao Jianmin; Yu Junbao; Yin Xiuli] YICCAS, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Ji Chenglong; Liu Xiaoli] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
通讯作者Wu, HF (reprint author), Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res YIC, Yantai 264003, Peoples R China. hfwu@yic.ac.cn
文献子类Article
英文摘要Ruditapes philippinarum, a clam that thrives in intertidal zones of various salinities, is a useful biomonitor to marine contaminants. We investigated the influence of dilution to 75% and 50% of normal seawater salinity (31.1) on the responses of the digestive gland of R. philippinarum to arsenic exposure (20 mu g/L), using nuclear magnetic resonance (NMR)-based metabolomics. After acute arsenic exposure for 48 h, salinity-dependent differential metabolic responses were detected. In normal seawater, arsenic exposure increased the concentrations of branched-chain amino acids, and of threonine, proline, phosphocholine and adenosine, and it decreased the levels of alanine, hypotaurine, glucose, glycogen and ATP in the digestive glands. Differential changes in metabolic biomarkers observed at lower salinity (similar to 23.3) included elevation of succinate, taurine and ATP, and depletion of branched-chain amino acids, threonine and glutamine. Unique effects of arsenic at the lowest salinity (similar to 15.6) included down-regulation of glutamate, succinate and ADP, and up-regulation of phosphocholine. We conclude that salinity influences the metabolic responses of this clam to arsenic.; Ruditapes philippinarum, a clam that thrives in intertidal zones of various salinities, is a useful biomonitor to marine contaminants. We investigated the influence of dilution to 75% and 50% of normal seawater salinity (31.1) on the responses of the digestive gland of R. philippinarum to arsenic exposure (20 mu g/L), using nuclear magnetic resonance (NMR)-based metabolomics. After acute arsenic exposure for 48 h, salinity-dependent differential metabolic responses were detected. In normal seawater, arsenic exposure increased the concentrations of branched-chain amino acids, and of threonine, proline, phosphocholine and adenosine, and it decreased the levels of alanine, hypotaurine, glucose, glycogen and ATP in the digestive glands. Differential changes in metabolic biomarkers observed at lower salinity (similar to 23.3) included elevation of succinate, taurine and ATP, and depletion of branched-chain amino acids, threonine and glutamine. Unique effects of arsenic at the lowest salinity (similar to 15.6) included down-regulation of glutamate, succinate and ADP, and up-regulation of phosphocholine. We conclude that salinity influences the metabolic responses of this clam to arsenic.
学科主题Limnology ; Oceanography
URL标识查看原文
WOS关键词NUCLEAR-MAGNETIC-RESONANCE ; NMR-BASED METABOLOMICS ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; PATTERN-RECOGNITION ; H-1-NMR SPECTROSCOPY ; TAPES-PHILIPPINARUM ; MANILA CLAMS ; RESPONSES ; METABONOMICS ; TOXICITY
WOS研究方向Marine & Freshwater Biology ; Oceanography
语种英语
WOS记录号WOS:000316018300010
资助机构National Natural Science Foundation of China [41106102]; Natural Science Foundation of Shandong Province [ZR2009CZ008]; 100 Talents Program of Chinese Academy of Sciences
公开日期2013-08-15
源URL[http://ir.yic.ac.cn/handle/133337/6679]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
烟台海岸带研究所_滨海湿地实验室
作者单位1.Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res YIC, Yantai 264003, Peoples R China
2.YICCAS, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Ji Chenglong,Wu Huifeng,Liu Xiaoli,et al. The influence of salinity on toxicological effects of arsenic in digestive gland of clam Ruditapes philippinarum using metabolomics[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2013,31(2):345-352.
APA Ji Chenglong,Wu Huifeng,Liu Xiaoli,Zhao Jianmin,Yu Junbao,&Yin Xiuli.(2013).The influence of salinity on toxicological effects of arsenic in digestive gland of clam Ruditapes philippinarum using metabolomics.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,31(2),345-352.
MLA Ji Chenglong,et al."The influence of salinity on toxicological effects of arsenic in digestive gland of clam Ruditapes philippinarum using metabolomics".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 31.2(2013):345-352.

入库方式： OAI收割

来源：烟台海岸带研究所

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