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Exploiting endogenous fibrocartilage stem cells to regenerate cartilage and repair joint injury
文献类型：期刊论文
| 作者 | Embree, Mildred C.; Chen, Mo; Pylawka, Serhiy; Kong, Danielle; Iwaoka, George M.; Kalajzic, Ivo; Yao, Hai; Shi, Chancheng; Sun, Dongming; Sheu, Tzong-Jen |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2016 |
| 卷号 | 7 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/ncomms13073 |
| 通讯作者 | Embree, MC (reprint author), Columbia Univ, Coll Dent Med, Med Ctr, TMJ Biol & Regenerat Med Lab, 630 W 168th St,P&S 16-440, New York, NY 10032 USA. |
| 英文摘要 | Tissue regeneration using stem cell-based transplantation faces many hurdles. Alternatively, therapeutically exploiting endogenous stem cells to regenerate injured or diseased tissue may circumvent these challenges. Here we show resident fibrocartilage stem cells (FCSCs) can be used to regenerate and repair cartilage. We identify FCSCs residing within the superficial zone niche in the temporomandibular joint (TMJ) condyle. A single FCSC spontaneously generates a cartilage anlage, remodels into bone and organizes a haematopoietic microenvironment. Wnt signals deplete the reservoir of FCSCs and cause cartilage degeneration. We also show that intra-articular treatment with the Wnt inhibitor sclerostin sustains the FCSC pool and regenerates cartilage in a TMJ injury model. We demonstrate the promise of exploiting resident FCSCs as a regenerative therapeutic strategy to substitute cell transplantation that could be beneficial for patients suffering from fibrocartilage injury and disease. These data prompt the examination of utilizing this strategy for other musculoskeletal tissues. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000385546900001 |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/4369]  |
| 专题 | 中国科学院重庆绿色智能技术研究院 |
| 作者单位 | (1) Columbia Univ, Coll Dent Med, Med Ctr, TMJ Biol & Regenerat Med Lab, 630 W 168th St,P&S 16-440, New York, NY 10032 USA; (2) Columbia Univ, Coll Dent Med, Med Ctr, Ctr Craniofacial Regenerat, 622 W 168th St, New York, NY 10032 USA; (3) Univ Connecticut, Hlth Sci Ctr, Dept Reconstruct Sci, MC3705,L7005,263 Farmington Ave, Farmington, CT 06032 USA; (4) Clemson Univ, Dept Bioengn, Clemson MUSC Bioengn Program, 173 Ashley Ave,MSC 508, Charleston, SC 29425 USA; (5) Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, 266 Fangzheng Ave,Shuitu Hitech Ind Pk, Chongqing 400714, Peoples R China; (6) Rutgers State Univ, WM Keck Ctr Collaborat Neurosci, 604 Allison Rd,D 251, Piscataway, NJ 08854 USA; (7) Univ Rochester, Med Ctr, Ctr Musculoskeletal Res, 601 Elmwood Ave,Box 665, Rochester, NY 14620 USA; (8) Metropolitan Oral Surg Associates, 488 Madison Ave 200, New York, NY 10022 USA; [Koch, Alia(9) Columbia Univ, Med Ctr, Div Oral & Maxillofacial Surg, Coll Dent Med, 622 W 168th St, New York, NY 10032 USA |
| 推荐引用方式 GB/T 7714 | Embree, Mildred C.,Chen, Mo,Pylawka, Serhiy,et al. Exploiting endogenous fibrocartilage stem cells to regenerate cartilage and repair joint injury[J]. NATURE COMMUNICATIONS,2016,7. |
| APA | Embree, Mildred C..,Chen, Mo.,Pylawka, Serhiy.,Kong, Danielle.,Iwaoka, George M..,...&Mao, Jeremy J..(2016).Exploiting endogenous fibrocartilage stem cells to regenerate cartilage and repair joint injury.NATURE COMMUNICATIONS,7. |
| MLA | Embree, Mildred C.,et al."Exploiting endogenous fibrocartilage stem cells to regenerate cartilage and repair joint injury".NATURE COMMUNICATIONS 7(2016). |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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