中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Mechanistic toxicity of DEHP at environmentally relevant concentrations (ERCs) and ecological risk assessment in the Three Gorges Reservoir Area, China

文献类型:期刊论文

作者Junaid, Muhammad1,2; Jia, Pan-Pan1,2; Tang, Yu-Mei1,2; Xiong, Wen-Xu1; Huang, Hai-Yang1; Strauss, Phyllis R.3; Li, Wei-Guo4; Pei, De-Sheng1,4
刊名ENVIRONMENTAL POLLUTION
出版日期2018-11-01
卷号242页码:1939-1949
ISSN号0269-7491
关键词Ercs Dehp In Vitro/vivo Assays Ecological Risks Toxicity Assessment Zebrafish
DOI10.1016/j.envpol.2018.07.067
英文摘要

Di-(2-ethylhexyl) phthalate (DEHP) associated in vitro/vivo toxicity at current environmentally relevant concentration (ERC) with attendant ecological risks in the Three Gorges Reservoir Area (TGRA) is still elusive. Responding to this challenge, a novel integrated study based on analytical and biological assays was designed to elucidate the underlying mechanisms for toxicity of DEHP and its ecological risks at ERC. In this study, GC-MS analysis showed that the highest environmental concentration of DEHP in the TGRA surface water was nearly double that of WHO and USEPA standards. Both distribution and ecological risk decreased from the upper to middle and lower reaches of the TGRA. In vitro toxicity was assessed by cell viability and DNA damage assays: DEHP exposure at ERCs (100-800 mu g/L) caused significant reduction in cell viability and elevated DNA damage. Further, DEHP exposure above 400 mu g/L resulted in enhanced migration behavior of cancer cells. For in vivo toxicity assessment, short term acute exposure (7 d, 400 mu g/L) apparently activated the PI3K-AKT-mTOR pathway, and chronic low-level exposure (3 months, 10 -33 mu g/L) suppressed the hypothalamus pituitary thyroid (HPT) axis pathway in zebrafish. In addition, acute low-level exposure (5 d, 33-400 mu g/L) to DEHP increased aryl hydrocarbon receptor (AhR) activity in Tg(cyp1a:gfp) zebrafish in a concentration-dependent manner. In short, DEHP at ERC has extended potential to induce diverse in vitro and in vivo toxicity at concentrations that also cause impairment of biochemical function in aquatic species of the TGRA. (C) 2018 Elsevier Ltd. All rights reserved.

资助项目Three Hundred Leading Talents in Scientific and Technological Innovation Program of Chongqing[CSTCCXLJRC201714] ; Key Application and Development Program of Chongqing Science and Technology Commission[cstc2014yykfC20004] ; Key Application and Development Program of Chongqing Science and Technology Commission[cstc2014yykfC20002] ; Chinese Academy of Sciences ; UCAS Scholarship[2015A8018508421]
WOS研究方向Environmental Sciences & Ecology
语种英语
出版者ELSEVIER SCI LTD
WOS记录号WOS:000446282600097
源URL[http://119.78.100.138/handle/2HOD01W0/6834]  
专题环境与健康研究中心
作者单位1.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Key Lab Reservoir Aquat Environm, Chongqing 400714, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Northeastern Univ, Coll Sci, Dept Biol, Boston, MA 02115 USA
4.Henan Normal Univ, Coll Life Sci, Xinxiang 453007, Peoples R China
推荐引用方式
GB/T 7714
Junaid, Muhammad,Jia, Pan-Pan,Tang, Yu-Mei,et al. Mechanistic toxicity of DEHP at environmentally relevant concentrations (ERCs) and ecological risk assessment in the Three Gorges Reservoir Area, China[J]. ENVIRONMENTAL POLLUTION,2018,242:1939-1949.
APA Junaid, Muhammad.,Jia, Pan-Pan.,Tang, Yu-Mei.,Xiong, Wen-Xu.,Huang, Hai-Yang.,...&Pei, De-Sheng.(2018).Mechanistic toxicity of DEHP at environmentally relevant concentrations (ERCs) and ecological risk assessment in the Three Gorges Reservoir Area, China.ENVIRONMENTAL POLLUTION,242,1939-1949.
MLA Junaid, Muhammad,et al."Mechanistic toxicity of DEHP at environmentally relevant concentrations (ERCs) and ecological risk assessment in the Three Gorges Reservoir Area, China".ENVIRONMENTAL POLLUTION 242(2018):1939-1949.

入库方式: OAI收割

来源:重庆绿色智能技术研究院

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