Label-free detection of anti-estrogen receptor alpha and its binding with estrogen receptor peptide alpha by terahertz spectroscopy
文献类型：期刊论文
| 作者 | Li, Mingliang1; Chang, Tianying1,2; Wei, Dongshan2; Tang, Mingjie2 ; Yan, Shihan2; Du, Chunlei2; Cui, Hong-Liang1,2
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| 刊名 | RSC ADVANCES
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| 出版日期 | 2017 |
| 卷号 | 7期号:39页码:24338-24344 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c6ra28754a |
| 通讯作者 | Chang, TY (reprint author), Jilin Univ, Coll Instrumentat & Elect Engn, Changchun 130061, Jilin, Peoples R China. ; Chang, TY ; Wei, DS (reprint author), Chinese Acad Sci, Chongqing Key Lab Multiscale Mfg Technol, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China. |
| 英文摘要 | Terahertz (THz) spectroscopic techniques were employed to study the hydration shell formation around anti-estrogen receptor alpha (AER-alpha), an important biomarker in breast cancer diagnosis, and to detect the binding reaction between AER-alpha and estrogen receptor peptide alpha (ERP-alpha), in aqueous solutions. A remarkable nonlinear relation between THz absorption and AER-alpha concentration was demonstrated, shedding some light on the formation process of the hydration shell around AER-alpha. THz spectroscopic properties of the AER-alpha were also shown to be significantly affected by the binding with the ERP-alpha, to the extent that THz transmission and attenuation could be used to investigate the dielectric properties of antibody-antigen binding reactions. |
| URL标识 | 查看原文 |
| 资助项目 | Chinese Ministry of Science and Technology[2012BAK04B03] ; National 973 Program of China[2015CB755401] ; Chongqing Science and Technology Commission[cstc2013jcyjC00001] ; Chongqing Science and Technology Commission[cstc2013yykfC00007] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000401525500052 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/3660]  |
| 专题 | 太赫兹技术研究中心 微纳制造与系统集成研究中心 |
| 通讯作者 | Chang, Tianying; Wei, Dongshan |
| 作者单位 | 1.Jilin Univ, Coll Instrumentat & Elect Engn, Changchun 130061, Jilin, Peoples R China 2.Chinese Acad Sci, Chongqing Key Lab Multiscale Mfg Technol, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Mingliang,Chang, Tianying,Wei, Dongshan,et al. Label-free detection of anti-estrogen receptor alpha and its binding with estrogen receptor peptide alpha by terahertz spectroscopy[J]. RSC ADVANCES,2017,7(39):24338-24344. |
| APA | Li, Mingliang.,Chang, Tianying.,Wei, Dongshan.,Tang, Mingjie.,Yan, Shihan.,...&Cui, Hong-Liang.(2017).Label-free detection of anti-estrogen receptor alpha and its binding with estrogen receptor peptide alpha by terahertz spectroscopy.RSC ADVANCES,7(39),24338-24344. |
| MLA | Li, Mingliang,et al."Label-free detection of anti-estrogen receptor alpha and its binding with estrogen receptor peptide alpha by terahertz spectroscopy".RSC ADVANCES 7.39(2017):24338-24344. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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