Terahertz spectroscopy of oligonucleotides in aqueous solutions
文献类型：期刊论文
| 作者 | Tang, Mingjie ; Huang, Qing; Wei, Dongshan; Zhao, Guozhong; Chang, Tianying; Kou, Kuan; Wang, Min; Du, Chunlei; Fu, Wei-ling; Cui, Hong-Liang
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| 刊名 | JOURNAL OF BIOMEDICAL OPTICS
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| 出版日期 | 2015 |
| 卷号 | 20期号:9 |
| ISSN号 | 1083-3668 |
| DOI | 10.1117/1.JBO.20.9.095009 |
| 通讯作者 | Cui, HL (reprint author), Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing Key Lab Multi Scale Mfg Technol, 266 Fangzheng Ave,Shuitu Hitech Ind Pk, Chongqing 400714, Peoples R China. |
| 英文摘要 | A terahertz (THz) spectroscopic study is carried out to analyze DNA mutations in a label-free manner. Three newly designed liquid sample cells are considered and the best is selected as the sample carrier for THz transmission spectroscopic analyses. Discrimination based on spectral signatures of single-base mutations on single-stranded 20 nt oligonucleotides has been shown possible experimentally. The results clearly attest the ability of this promising approach for label-free analyses of single-base mutations of DNA molecules. This study has demonstrated that the THz spectroscopic technology can be considered as a potential diagnostic tool for investigating molecular reactions, such as DNA mutations. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE) |
| 语种 | 英语 |
| WOS记录号 | WOS:000365128100013 |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/4332]  |
| 专题 | 太赫兹技术研究中心 微纳制造与系统集成研究中心 |
| 作者单位 | (1) Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing Key Lab Multi Scale Mfg Technol, Chongqing 400714, Peoples R China; (2) Third Mil Med Univ, Southwest Hosp, Dept Lab Med, Chongqing 400038, Peoples R China; (3) Capital Normal Univ, Dept Phys, Beijing 100048, Peoples R China; (4) Jilin Univ, Coll Instrumentat Sci & Elect Engn, Changchun 130061, Jilin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Mingjie,Huang, Qing,Wei, Dongshan,et al. Terahertz spectroscopy of oligonucleotides in aqueous solutions[J]. JOURNAL OF BIOMEDICAL OPTICS,2015,20(9). |
| APA | Tang, Mingjie.,Huang, Qing.,Wei, Dongshan.,Zhao, Guozhong.,Chang, Tianying.,...&Cui, Hong-Liang.(2015).Terahertz spectroscopy of oligonucleotides in aqueous solutions.JOURNAL OF BIOMEDICAL OPTICS,20(9). |
| MLA | Tang, Mingjie,et al."Terahertz spectroscopy of oligonucleotides in aqueous solutions".JOURNAL OF BIOMEDICAL OPTICS 20.9(2015). |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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