Characterization of Glucosamine and Collagen crystallization by terahertz time-domain spectroscopy
文献类型：会议论文
| 作者 | Shi, Changcheng1; Wei, Dongshan1; Du, Chunlei1 ; Cui, Hongliang1; Ma, Yuting2
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| 出版日期 | 2016 |
| 会议日期 | July 18, 2016 - July 22, 2016 |
| 会议地点 | Chongqing, China |
| DOI | 10.1109/3M-NANO.2016.7824982 |
| 页码 | 414-417 |
| 英文摘要 | Terahertz time-domain spectroscopy (THz-TDS) has been demonstrated as a promising solid-state analytical tool which can probe intermolecular interactions through crystal lattice vibrations. However, the current studies commonly investigate the interactions between two biological or pharmaceutical molecules with relatively low molecular weights. The interaction between small biomolecule and biomacromolecule in the crystallization process has not been reported. In this study, THz-TDS was used as a novel technique to characterize the interaction between small biomolecule (Glucosamine) and biomacromolecule (Collagen) in the crystallization process. The absence of THz absorption peak in solvent mixed sample with weight ratio of 1:1 showed the crystallization process of glucosamine was disturbed by collagen. The recurrence of THz absorption peak in solvent mixed sample with weight ratio of 7:1 may be related to the saturation of interaction between glucosamine and collagen. The dissolving and lyophilizing processes were validated to hardly affect the crystal formation of glucosamine. This study further demonstrates THZ-TDS has the capability to characterize the interaction between small biomolecule and biomacromolecule in solid-state. © 2016 IEEE. |
| 会议录 | 6th IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, IEEE 3M-NANO 2016
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| 语种 | 英语 |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/4647]  |
| 专题 | 太赫兹技术研究中心 微纳制造与系统集成研究中心 |
| 作者单位 | 1.Research Center for THz Technology, Chongqing Key Lab of Multi-scale Manufacturing Technology, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, China; 2.College of Instrumentation and Electrical Engineering, Jilin University, Changchun, China |
| 推荐引用方式 GB/T 7714 | Shi, Changcheng,Wei, Dongshan,Du, Chunlei,et al. Characterization of Glucosamine and Collagen crystallization by terahertz time-domain spectroscopy[C]. 见:. Chongqing, China. July 18, 2016 - July 22, 2016. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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