Cell viability and hydration assay based on metamaterial-enhanced terahertz spectroscopy
文献类型：期刊论文
| 作者 | Liu, Yu1; Tang, Mingjie2 ; Xia, Liangping2; Yu, Wenjing1; Peng, Jia1; Zhang, Yang1; de la Chapelle, Marc Lamy3; Yang, Ke1; Cui, Hong-Liang2,4; Fu, Weiling1
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| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:85页码:53963-53969 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c7ra09609g |
| 英文摘要 | As a fast-growing technology, terahertz time-domain spectroscopy (THz-TDS) is becoming increasingly pervasive in biological applications, targeting a range of biomaterials from biomolecules to tissues. However, THz-TDS studies at the cellular level are quite limited. Thus, a study to analyze the living state and hydration state of a tumor cell in a label-free manner is carried out and reported here. Combined with a specially designed THz metamaterial, a tumor cell monolayer was detected continuously over a period of time. In addition, in order to explore the possible impact of the metamaterial on tumor cells, the secretion of IL-6, IL-8, GM-CSF and GRO alpha of cell supernatants was detected. The results demonstrated that the technology could characterize the living state by monitoring the extracellular water and investigate the hydration state inside a tumor cell in real time, showing great application potential for the label-free detection of normal cells and tumor cells of diverse malignant degree. |
| 资助项目 | National Basic Research Program of China (Program 973) of China[2015CB755400] ; National Natural Science Foundation of China[81430054] ; Military Medical Pre-research Funds of The Third Military Medical University[SWH2013JS05] ; Physics and Biomedical Cross Laboratory Incubator Funds[WSS-2014-08] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000416831000036 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://172.16.51.4:88/handle/2HOD01W0/281]  |
| 专题 | 太赫兹技术研究中心 |
| 通讯作者 | Cui, Hong-Liang; Fu, Weiling |
| 作者单位 | 1.Third Mil Med Univ, Southwest Hosp, Dept Lab Med, Chongqing 400038, Peoples R China 2.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing Key Lab Multiscale Mfg Technol, Chongqing 400714, Peoples R China 3.Univ Paris 13, CNRS, Lab CSPBAT, UMR 7244,Sorbonne Paris Cite, 74 Rue Marcel Cachin, F-93017 Bobigny, France 4.Jilin Univ, Coll Instrumentat Sci & Elect Engn, Changchun 130061, Jilin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yu,Tang, Mingjie,Xia, Liangping,et al. Cell viability and hydration assay based on metamaterial-enhanced terahertz spectroscopy[J]. RSC ADVANCES,2017,7(85):53963-53969. |
| APA | Liu, Yu.,Tang, Mingjie.,Xia, Liangping.,Yu, Wenjing.,Peng, Jia.,...&Fu, Weiling.(2017).Cell viability and hydration assay based on metamaterial-enhanced terahertz spectroscopy.RSC ADVANCES,7(85),53963-53969. |
| MLA | Liu, Yu,et al."Cell viability and hydration assay based on metamaterial-enhanced terahertz spectroscopy".RSC ADVANCES 7.85(2017):53963-53969. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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