Rapid and label-free detection and assessment of bacteria by terahertz time-domain spectroscopy
文献类型：期刊论文
| 作者 | Yang, Xiang1; Wei, Dongshan2; Yan, Shihan2 ; Liu, Yueping1; Yu, Shu1; Zhang, Mingkun2; Yang, Zhongbo2; Zhu, Xiaoyan1; Huang, Qing1; Cui, Hong-Liang2,3
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| 刊名 | JOURNAL OF BIOPHOTONICS
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| 出版日期 | 2016-10-01 |
| 卷号 | 9期号:10页码:1050-1058 |
| 关键词 | bacterial analysis laboratory medicine terahertz time-domain spectroscopy absorption coefficient |
| ISSN号 | 1864-063X |
| DOI | 10.1002/jbio.201500270 |
| 通讯作者 | Fu, WL (reprint author), Third Mil Med Univ, Southwest Hosp, Dept Lab Med, Chongqing 400038, Peoples R China. ; Cui, HL (reprint author), Chinese Acad Sci, Chongqing Key Lab Multiscale Mfg Technol, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China. ; Cui, HL (reprint author), Jilin Univ, Coll Instrumentat Sci & Elect Engn, Changchun 130061, Jilin, Peoples R China. |
| 英文摘要 | Here we demonstrated the potential and applicability of terahertz (THz) spectroscopy to detect four commonly found bacteria in the infectious diseases. Besides the different spectral characteristics between bacterial species, THz absorption differences for living bacteria, dead bacteria and bacterial powder of the same species were also investigated. Our results revealed that small differences in water contents between bacterial cells account for distinct discrepancies of the absorption coefficients, which can be used for bacterial species identification. Furthermore, living and dead bacteria showed different absorption coefficients as a result of their different hydration levels, suggesting that THz spectroscopy can be used to rapidly assess the living state of bacteria under test. Our results clearly demonstrated the ability of THz spectroscopy for time-saving and label-free detection of bacteria with minimal sample preparation, potentially to be utilized for point-of-care tests in the near future. [GRAPHICS] Schematic representation of bacterial detection by THz spectroscopy. Different bacteria have distinctive absorption coefficients as a result of their different water contents. |
| 资助项目 | National Basic Research Program of China[2015CB755400] ; National Natural Science Foundation of China[81430054] ; Military Medical Pre-research Funds of The Third Military Medical University[SWH2013JS05] ; Physics and Biomedical Cross Laboratory Incubator Funds[WSS-2014-08] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics ; Optics |
| 语种 | 英语 |
| WOS记录号 | WOS:000388372800008 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/3090]  |
| 专题 | 太赫兹技术研究中心 |
| 通讯作者 | Cui, Hong-Liang; Fu, Weiling |
| 作者单位 | 1.Third Mil Med Univ, Southwest Hosp, Dept Lab Med, Chongqing 400038, Peoples R China 2.Chinese Acad Sci, Chongqing Key Lab Multiscale Mfg Technol, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China 3.Jilin Univ, Coll Instrumentat Sci & Elect Engn, Changchun 130061, Jilin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Xiang,Wei, Dongshan,Yan, Shihan,et al. Rapid and label-free detection and assessment of bacteria by terahertz time-domain spectroscopy[J]. JOURNAL OF BIOPHOTONICS,2016,9(10):1050-1058. |
| APA | Yang, Xiang.,Wei, Dongshan.,Yan, Shihan.,Liu, Yueping.,Yu, Shu.,...&Fu, Weiling.(2016).Rapid and label-free detection and assessment of bacteria by terahertz time-domain spectroscopy.JOURNAL OF BIOPHOTONICS,9(10),1050-1058. |
| MLA | Yang, Xiang,et al."Rapid and label-free detection and assessment of bacteria by terahertz time-domain spectroscopy".JOURNAL OF BIOPHOTONICS 9.10(2016):1050-1058. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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