Evaluation of the diagnostic potential of ex vivo Raman spectroscopy in gastric cancers: fingerprint versus high wavenumber
文献类型：期刊论文
| 作者 | Zhou, Xueqian; Dai, Jianhua; Chen, Yao; Duan, Guangjie; Liu, Yulong; Zhang, Hua ; Wu, Hongbo; Peng, Guiyong
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| 刊名 | JOURNAL OF BIOMEDICAL OPTICS
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| 出版日期 | 2016 |
| 卷号 | 21期号:10 |
| ISSN号 | 1083-3668 |
| DOI | 10.1117/1.JBO.21.10.105002 |
| 通讯作者 | Peng, GY (reprint author), Third Mil Med Univ, Southwest Hosp, Inst Digest Dis, 30 Gaotanyan St, Chongqing 400038, Peoples R China. |
| 英文摘要 | The aim of this study was to apply Raman spectroscopy in the high wavenumber (HW) region (2800 to 3000 cm(-1)) for ex vivo detection of gastric cancer and compare its diagnostic potential with that of the fingerprint (FP) region (800 to 1800 cm(-1)). Raman spectra were collected in the FP and HW regions to differentiate between normal mucosa (n = 38) and gastric cancer (n = 37). The distinctive Raman spectral differences between normal and cancer tissues are observed at 853, 879, 1157, 1319, 1338, 1448, and 2932 cm(-1) and are primarily related to proteins, lipids, nucleic acids, collagen, and carotenoids in the tissue. In FP and HW Raman spectroscopy for diagnosis of gastric cancer, multivariate diagnostic algorithms based on partial-least-squares discriminant analysis, together with leave-one-sample-out cross validation, yielded diagnostic sensitivities of 94.59% and 81.08%, and specificities of 86.84% and 71.05%, respectively. Receiver operating characteristic analysis further confirmed that the FP region model performance is superior to that of the HW region model. Better differentiation between normal and gastric cancer tissues can be achieved using FP Raman spectroscopy and PLS-DA techniques, but the complementary natures of the FP and HW regions make both of them useful in diagnosis of gastric cancer. (C) 2016 Society of Photo-Optical Instrumentation Engineers (SPIE) |
| 语种 | 英语 |
| WOS记录号 | WOS:000388213300020 |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/4370]  |
| 专题 | 太赫兹技术研究中心 |
| 作者单位 | (1) Third Mil Med Univ, Southwest Hosp, Inst Digest Dis, 30 Gaotanyan St, Chongqing 400038, Peoples R China; (2) Third Mil Med Univ, Inst Pathol, 30 Gaotanyan St, Chongqing 400038, Peoples R China; (3) Third Mil Med Univ, Southwest Hosp, Southwest Canc Ctr, 30 Gaotanyan St, Chongqing 400038, Peoples R China; (4) Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Key Lab Multiscale Mfg Technol, 266 Fangzheng Ave,Shuitu Hitech Ind Pk, Chongqing 400714, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Xueqian,Dai, Jianhua,Chen, Yao,et al. Evaluation of the diagnostic potential of ex vivo Raman spectroscopy in gastric cancers: fingerprint versus high wavenumber[J]. JOURNAL OF BIOMEDICAL OPTICS,2016,21(10). |
| APA | Zhou, Xueqian.,Dai, Jianhua.,Chen, Yao.,Duan, Guangjie.,Liu, Yulong.,...&Peng, Guiyong.(2016).Evaluation of the diagnostic potential of ex vivo Raman spectroscopy in gastric cancers: fingerprint versus high wavenumber.JOURNAL OF BIOMEDICAL OPTICS,21(10). |
| MLA | Zhou, Xueqian,et al."Evaluation of the diagnostic potential of ex vivo Raman spectroscopy in gastric cancers: fingerprint versus high wavenumber".JOURNAL OF BIOMEDICAL OPTICS 21.10(2016). |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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