Slowing down DNA translocation by a nanofiber meshed layer
文献类型：期刊论文
| 作者 | Zhao, Yue; Xie, Wanyi ; Tian, Enling; Ren, Yiwei; Zhu, Jifeng; Deng, Yunsheng; He, Shixuan; Liang, Liyuan; Wang, Yunjiao; Zhou, Daming
|
| 刊名 | JOURNAL OF PHYSICS D-APPLIED PHYSICS
 |
| 出版日期 | 2018-01-31 |
| 卷号 | 51期号:4页码:6 |
| 关键词 | solid-state nanopore nanofiber DNA sequencing Poisson-Nernst-Planck equation |
| ISSN号 | 0022-3727 |
| DOI | 10.1088/1361-6463/aa9ec8 |
| 英文摘要 | Due to the weak interaction between DNA molecules and the inner surface of nanopores, DNA translocation is very fast, just leaving a short current drop without sufficient information to recognise the nucleotide sequence in the strand. In this paper, we propose a nanopore-nanofiber mesh hybridized structure to decelerate DNA translocation speed. Experimental results reveal that due to hydrophobic interaction between the DNA fragments and the nanofibers, the DNA moving speed can be retarded to two orders of magnitude slower. Furthermore, according to theory simulations, the additional fiber layer will reduce the electric field in the channel but elongate the capture region at the pore orifice, which will be helpful for increasing the capture rate and extending the DNA dwelling time in the meanwhile. |
| 资助项目 | Instrument Development Program of Chinese Academy of Sciences[YZ201568] ; National Natural Science Foundations of China NNSFC[61701474] ; West Light Foundation of CAS ; Chongqing Sci. & Technol. Commission ; NNSFC[61471336] ; NNSFC[21507131] ; NNSFC[51503206] ; NNSFC[61504146] |
| WOS研究方向 | Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000419615200001 |
| 出版者 | IOP PUBLISHING LTD |
| 源URL | [http://172.16.51.4:88/handle/2HOD01W0/81]  |
| 专题 | 精准医疗单分子诊断技术研究中心 中国科学院重庆绿色智能技术研究院 |
| 通讯作者 | Zhao, Yue |
| 作者单位 | Chongqing Inst Green & Intelligent Technol, Chongqing Key Lab Multiscale Mfg Technol, Chongqing 400714, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Yue,Xie, Wanyi,Tian, Enling,et al. Slowing down DNA translocation by a nanofiber meshed layer[J]. JOURNAL OF PHYSICS D-APPLIED PHYSICS,2018,51(4):6. |
| APA | Zhao, Yue.,Xie, Wanyi.,Tian, Enling.,Ren, Yiwei.,Zhu, Jifeng.,...&Wang, Deqiang.(2018).Slowing down DNA translocation by a nanofiber meshed layer.JOURNAL OF PHYSICS D-APPLIED PHYSICS,51(4),6. |
| MLA | Zhao, Yue,et al."Slowing down DNA translocation by a nanofiber meshed layer".JOURNAL OF PHYSICS D-APPLIED PHYSICS 51.4(2018):6. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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