Detecting Interactions between Nanomaterials and Cell Membranes by Synthetic Nanopores
文献类型：期刊论文
| 作者 | Luan, Binquan; Zhou, Shuo ; Wang, Deqiang; Zhou, Ruhong
|
| 刊名 | ACS NANO
 |
| 出版日期 | 2017 |
| 卷号 | 11期号:12页码:12615-12623 |
| 关键词 | bionano nanotoxicity nanopore biosensor membrane damage graphene nanomaterials |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.7b07005 |
| 通讯作者 | Luan, BQ ; Zhou, RH (reprint author), IBM Thomas J Watson Res, Computat Biol Ctr, Yorktown Hts, NY 10598 USA. |
| 英文摘要 | Engineered nanomaterials have been increasingly utilized in industry for various consumer products, environmental treatments, energy storage, and biomedical applications. Meanwhile, it has been established that certain nanomaterials can be toxic to biological cells from extensive experimental and theoretical studies. Despite that the exact molecular mechanisms of this nanomaterial toxicity are still not well understood, it is ubiquitous that their interactions with cell membranes, through either endocytosis or penetration (and thus potential lysis), act as the first step toward the inflammation or even the death of a cell. To facilitate the study of nanomaterial-membrane interactions, here we demonstrate a nanopore-based single-molecule approach that can be applied to monitor a specific nanomaterial-membrane interaction in real time. Combined with molecular dynamics and experimental approaches, we show how an ionic current can be used to detect membrane damage by a graphene nanosheet and illustrate the underlying molecular mechanism. More generally, we expect that measured transmembrane ionic currents (both DC and AC) can signify many particle-induced membrane modifications, such as hole formation, particle adsorption, and protein insertion. |
| 资助项目 | IBM Bluegene Science Program[W125859] ; IBM Bluegene Science Program[W1464125] ; IBM Bluegene Science Program[W1464164] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000418990200091 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://172.16.51.4:88/handle/2HOD01W0/106]  |
| 专题 | 精准医疗单分子诊断技术研究中心 |
| 作者单位 | (1) IBM Thomas J Watson Res, Computat Biol Ctr, Yorktown Hts, NY 10598 USA; (2) Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luan, Binquan,Zhou, Shuo,Wang, Deqiang,et al. Detecting Interactions between Nanomaterials and Cell Membranes by Synthetic Nanopores[J]. ACS NANO,2017,11(12):12615-12623. |
| APA | Luan, Binquan,Zhou, Shuo,Wang, Deqiang,&Zhou, Ruhong.(2017).Detecting Interactions between Nanomaterials and Cell Membranes by Synthetic Nanopores.ACS NANO,11(12),12615-12623. |
| MLA | Luan, Binquan,et al."Detecting Interactions between Nanomaterials and Cell Membranes by Synthetic Nanopores".ACS NANO 11.12(2017):12615-12623. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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