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Monitoring tetracycline through a solid-state nanopore sensor

文献类型：期刊论文

作者Zhang, Yuechuan1,2; Chen, Yanling3; Fu, Yongqi1; Ying, Cuifeng2,4; Feng, Yanxiao2; Huang, Qimeng2; Wang, Chao3; Pei, De-Sheng3; Wang, Deqiang2
刊名SCIENTIFIC REPORTS
出版日期2016-06-16
卷号6页码:7
ISSN号2045-2322
DOI10.1038/srep27959
通讯作者Feng, YX ; Wang, DQ (reprint author), Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing Key Lab Multiscale Mfg Technol, Chongqing, Peoples R China. ; Pei, DS (reprint author), Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Res Ctr Environm & Hlth, Chongqing, Peoples R China.
英文摘要Antibiotics as emerging environmental contaminants, are widely used in both human and veterinary medicines. A solid-state nanopore sensing method is reported in this article to detect Tetracycline, which is based on Tet-off and Tet-on systems. rtTA (reverse tetracycline-controlled trans-activator) and TRE (Tetracycline Responsive Element) could bind each other under the action of Tetracycline to form one complex. When the complex passes through nanopores with 8 similar to 9 nanometers in diameter, we could detect the concentrations of Tet from 2 ng/mL to 2000 ng/mL. According to the Logistic model, we could define three growth zones of Tetracycline for rtTA and TRE. The slow growth zone is 0-39.5 ng/mL. The rapid growth zone is 39.5-529.7 ng/mL. The saturated zone is > 529.7 ng/mL. Compared to the previous methods, the nanopore sensor could detect and quantify these different kinds of molecule at the single-molecule level.
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资助项目Hundred Talents Program of Chinese Academy of Sciences ; National Natural Science Foundation of China[61471336] ; National Natural Science Foundation of China[61504146] ; National Natural Science Foundation of China[51503207] ; Key Application and Development Program of Chongqing Science and Technology Commission[cstc2014yykfC20004] ; Joint-Scholar of West-Light Foundation of the Chinese Academy of Sciences ; Instrument development program of CAS[YZ201568]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000378074400001
出版者NATURE PUBLISHING GROUP
源URL[http://119.78.100.138/handle/2HOD01W0/2572]  
专题精准医疗单分子诊断技术研究中心
环境与健康研究中心
通讯作者Feng, Yanxiao; Pei, De-Sheng; Wang, Deqiang
作者单位1.Univ Elect Sci & Technol China, Sch Phys Elect, Chengdu 610054, Peoples R China
2.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing Key Lab Multiscale Mfg Technol, Chongqing, Peoples R China
3.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Res Ctr Environm & Hlth, Chongqing, Peoples R China
4.Nankai Univ, Sch Phys, Minist Educ, Key Lab Weak Light Nonlinear Photon, Tianjin 300071, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Yuechuan,Chen, Yanling,Fu, Yongqi,et al. Monitoring tetracycline through a solid-state nanopore sensor[J]. SCIENTIFIC REPORTS,2016,6:7.
APA Zhang, Yuechuan.,Chen, Yanling.,Fu, Yongqi.,Ying, Cuifeng.,Feng, Yanxiao.,...&Wang, Deqiang.(2016).Monitoring tetracycline through a solid-state nanopore sensor.SCIENTIFIC REPORTS,6,7.
MLA Zhang, Yuechuan,et al."Monitoring tetracycline through a solid-state nanopore sensor".SCIENTIFIC REPORTS 6(2016):7.

入库方式： OAI收割

来源：重庆绿色智能技术研究院

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