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Physiological roles of mycothiol in detoxification and tolerance to multiple poisonous chemicals in Corynebacterium glutamicum

文献类型：期刊论文

作者Liu, Ying-Bao1,2; Long, Ming-Xiu3; Yin, Ya-Jie4; Si, Mei-Ru1,2; Zhang, Lei1,2; Lu, Zhi-Qiang5; Wang, Yao1,2; Shen, Xi-Hui1,2
刊名ARCHIVES OF MICROBIOLOGY
出版日期2013-06-01
卷号195期号:6页码:419-429
关键词Corynebacterium glutamicum Mycothiol Oxidative stress Detoxification
ISSN号0302-8933
DOI10.1007/s00203-013-0889-3
通讯作者Shen, XH (reprint author), Northwest A&F Univ, State Key Lab Crop Stress Biol Arid Areas, Yangling 712100, Shaanxi, Peoples R China.
英文摘要Mycothiol (MSH) plays important roles in maintaining cytosolic redox homeostasis and in adapting to reactive oxygen species in the high-(G + C)-content Gram-positive Actinobacteria. However, its physiological roles are ill defined compared to glutathione, the functional analog of MSH in Gram-negative bacteria and most eukaryotes. In this research, we explored the impact of intracellular MSH on cellular physiology by using MSH-deficient mutants in the model organism Corynebacterium glutamicum. We found that intracellular MSH contributes significantly to resistance to alkylating agents, glyphosate, ethanol, antibiotics, heavy metals and aromatic compounds. In addition, intracellular MSH is beneficial for withstanding oxidative stress induced by various oxidants in C. glutamicum. This study greatly expanded our current knowledge on the physiological functions of mycothiol in C. glutamicum and could be applied to improve the robustness of this scientifically and commercially important species in the future.
资助项目National Natural Science Foundation of China[31170121] ; National Natural Science Foundation of China[31170100] ; National Natural Science Foundation of China[31270078] ; Opening Project of State Key Laboratory of Microbial Resource, Institute of Microbiology, Chinese Academy of Sciences[SKLMR-20120601]
WOS研究方向Microbiology
语种英语
WOS记录号WOS:000319762200006
出版者SPRINGER
源URL[http://119.78.100.138/handle/2HOD01W0/559]  
专题中国科学院重庆绿色智能技术研究院
通讯作者Shen, Xi-Hui
作者单位1.Northwest A&F Univ, State Key Lab Crop Stress Biol Arid Areas, Yangling 712100, Shaanxi, Peoples R China
2.Northwest A&F Univ, Coll Life Sci, Yangling 712100, Shaanxi, Peoples R China
3.Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China
4.Chinese Acad Sci, Environm Microbiol & Ecol Res Ctr, Chongqing Inst Green & Intelligent Technol, Chongqing 401122, Peoples R China
5.Northwest A&F Univ, Coll Plant Protect, Yangling 712100, Shaanxi, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Ying-Bao,Long, Ming-Xiu,Yin, Ya-Jie,et al. Physiological roles of mycothiol in detoxification and tolerance to multiple poisonous chemicals in Corynebacterium glutamicum[J]. ARCHIVES OF MICROBIOLOGY,2013,195(6):419-429.
APA Liu, Ying-Bao.,Long, Ming-Xiu.,Yin, Ya-Jie.,Si, Mei-Ru.,Zhang, Lei.,...&Shen, Xi-Hui.(2013).Physiological roles of mycothiol in detoxification and tolerance to multiple poisonous chemicals in Corynebacterium glutamicum.ARCHIVES OF MICROBIOLOGY,195(6),419-429.
MLA Liu, Ying-Bao,et al."Physiological roles of mycothiol in detoxification and tolerance to multiple poisonous chemicals in Corynebacterium glutamicum".ARCHIVES OF MICROBIOLOGY 195.6(2013):419-429.

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来源：重庆绿色智能技术研究院

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