Metagenomic analysis of antibiotic resistance genes (ARGs) during refuse decomposition
文献类型：期刊论文
| 作者 | Liu, Xi1,2; Yang, Shu3,4; Wang, Yangqing1 ; Zhao, He-Ping5; Song, Liyan1
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| 刊名 | SCIENCE OF THE TOTAL ENVIRONMENT
 |
| 出版日期 | 2018-09-01 |
| 卷号 | 634页码:1231-1237 |
| 关键词 | Antibiotic resistance genes Metagenomics Refuse decomposition |
| ISSN号 | 0048-9697 |
| DOI | 10.1016/j.scitotenv.2018.04.048 |
| 英文摘要 | Landfill is important reservoirs of residual antibiotics and antibiotic resistance genes (ARGs), but themechanism of landfill application influence on antibiotic resistance remains unclear. Although refuse decomposition plays a crucial role in landfill stabilization, its impact on the antibiotic resistance has not been well characterized. To better understand the impact, we studied the dynamics of ARGs and the bacterial community composition during refuse decomposition in a bench-scale bioreactor after long term operation (265 d) based onmetagenomics analysis. The total abundances of ARGs increased from431.0 ppmin the initial aerobic phase (AP) to 643.9 ppmin the latermethanogenic phase (MP) during refuse decomposition, suggesting that application of landfill formunicipal solid waste (MSW) treatment may elevate the level of ARGs. A shift from drug-specific (bacitracin, tetracycline and sulfonamide) resistance to multidrug resistance was observed during the refuse decomposition and was driven by a shift of potential bacteria hosts. The elevated abundance of Pseudomonas mainly contributed to the increasing abundance of multidrug ARGs (mexF and mexW). Accordingly, the percentage of ARGs encoding an efflux pump increased during refuse decomposition, suggesting that potential bacteria hosts developed this mechanism to adapt to the carbon and energy shortage when biodegradable substances were depleted. Overall, our findings indicate that the use of landfill forMSW treatment increased antibiotic resistance, and demonstrate the need for a comprehensive investigation of antibiotic resistance in landfill. (C) 2018 Elsevier B.V. All rights reserved. |
| 资助项目 | Natural Science Foundation of China[51578528] ; Natural Science Foundation of China[51608506] |
| WOS研究方向 | Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:000433153600126 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/6479]  |
| 专题 | 环境友好化学过程研究中心 |
| 通讯作者 | Song, Liyan |
| 作者单位 | 1.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Environm Microbiol & Ecol Res Ctr, Chongqing 400714, Peoples R China 2.Univ Chinese Acad Sci, Beijing 101407, Peoples R China 3.Univ Utah, Dept Geol, Salt Lake City, UT 84112 USA 4.Univ Utah, Dept Geophys, Salt Lake City, UT 84112 USA 5.Zhejiang Univ, Environm & Resource Sci, Hangzhou 310058, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Xi,Yang, Shu,Wang, Yangqing,et al. Metagenomic analysis of antibiotic resistance genes (ARGs) during refuse decomposition[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2018,634:1231-1237. |
| APA | Liu, Xi,Yang, Shu,Wang, Yangqing,Zhao, He-Ping,&Song, Liyan.(2018).Metagenomic analysis of antibiotic resistance genes (ARGs) during refuse decomposition.SCIENCE OF THE TOTAL ENVIRONMENT,634,1231-1237. |
| MLA | Liu, Xi,et al."Metagenomic analysis of antibiotic resistance genes (ARGs) during refuse decomposition".SCIENCE OF THE TOTAL ENVIRONMENT 634(2018):1231-1237. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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