2-methoxycinnamaldehyde reduces IL-1 beta-induced prostaglandin production in rat cerebral endothelial cells
文献类型：期刊论文
| 作者 | Guo, Jian-You ; Huo, Hai-Ru; Yang, Yuan-Xiao; Li, Cang-Hai; Liu, Hong-Bin; Zhao, Bao-Sheng; Li, Lan-Fang; Ma, Yue-Ying; Guo, Shu-Ying; Jiang, Ting-Liang
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| 刊名 | BIOLOGICAL & PHARMACEUTICAL BULLETIN
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| 出版日期 | 2006-11-01 |
| 卷号 | 29期号:11页码:2214-2221 |
| 关键词 | 2-methoxycinnamaldehyde rat cerebral endothelial cell interleukin-1 beta cyclooxygenase prostaglandin E-2 |
| ISSN号 | 0918-6158 |
| 文献子类 | Article |
| 英文摘要 | Prostaglandin E-2 (PGE(2)) works as a common final mediator of the febrile. Guizhi-Tang, one of the most famous traditional Chinese medical formula used to treat influenza, common cold and other pyretic conditions, was previously reported to reduce the production of PGE(2) in rats. 2-Methoxycinnamaldehyde is a principle compound isolated from Guizhi-Tang. The aim of the present study was to investigate the effects of 2-methoxycinnamaldehyde on PGE(2) production of rat cerebral endothelial cells (CECs). 2-Methoxycinnamaldehyde dose-dependently inhibited interleukin (IL)-1 beta-induced PGE(2) production in CECs with IC50 values of 174 mu m. IL-1 beta stimulation increased the protein, activity and mRNA expression of cyclooxygenase (COX)-2 but not COX-1. 2-Methoxycinnamaldehyde reduced IL-1 beta-induced protein and activity of COX-2, but did not influence the COX-2 mRNA expression. Our results show that prostaglandin production in CECs during stimulated conditions is sensitive to inhibition by 2-methoxycinnamaldehyde and suggest that 2-methoxycinnamaldehyde may reduce COX-2 protein level and activity but not COX-2 mRNA.; Prostaglandin E-2 (PGE(2)) works as a common final mediator of the febrile. Guizhi-Tang, one of the most famous traditional Chinese medical formula used to treat influenza, common cold and other pyretic conditions, was previously reported to reduce the production of PGE(2) in rats. 2-Methoxycinnamaldehyde is a principle compound isolated from Guizhi-Tang. The aim of the present study was to investigate the effects of 2-methoxycinnamaldehyde on PGE(2) production of rat cerebral endothelial cells (CECs). 2-Methoxycinnamaldehyde dose-dependently inhibited interleukin (IL)-1 beta-induced PGE(2) production in CECs with IC50 values of 174 mu m. IL-1 beta stimulation increased the protein, activity and mRNA expression of cyclooxygenase (COX)-2 but not COX-1. 2-Methoxycinnamaldehyde reduced IL-1 beta-induced protein and activity of COX-2, but did not influence the COX-2 mRNA expression. Our results show that prostaglandin production in CECs during stimulated conditions is sensitive to inhibition by 2-methoxycinnamaldehyde and suggest that 2-methoxycinnamaldehyde may reduce COX-2 protein level and activity but not COX-2 mRNA. |
| 学科主题 | 生理心理学/生物心理学 |
| 语种 | 英语 |
| WOS记录号 | WOS:000242457300011 |
| 公开日期 | 2011-08-22 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/5111]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 通讯作者 | Hai-Ru HUO |
| 作者单位 | 1.Chinese Acad Chinese Med Sci, Inst Chinese Materia Med, Tang Ctr Herbal Med Res, Beijing 100700, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 3.Chinese Med Univ, Hangzhou 310053, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Jian-You,Huo, Hai-Ru,Yang, Yuan-Xiao,et al. 2-methoxycinnamaldehyde reduces IL-1 beta-induced prostaglandin production in rat cerebral endothelial cells[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2006,29(11):2214-2221. |
| APA | Guo, Jian-You.,Huo, Hai-Ru.,Yang, Yuan-Xiao.,Li, Cang-Hai.,Liu, Hong-Bin.,...&Hai-Ru HUO.(2006).2-methoxycinnamaldehyde reduces IL-1 beta-induced prostaglandin production in rat cerebral endothelial cells.BIOLOGICAL & PHARMACEUTICAL BULLETIN,29(11),2214-2221. |
| MLA | Guo, Jian-You,et al."2-methoxycinnamaldehyde reduces IL-1 beta-induced prostaglandin production in rat cerebral endothelial cells".BIOLOGICAL & PHARMACEUTICAL BULLETIN 29.11(2006):2214-2221. |
入库方式： OAI收割
来源：心理研究所
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