Activity and Toxicity of Cr(III)-Enriched Grifola frondosa in Insulin-Resistant Mice
文献类型：期刊论文
| 作者 | Xu, Qiang2; Guo, Jianyou1 ; J. Y. Guo
|
| 刊名 | BIOLOGICAL TRACE ELEMENT RESEARCH
 |
| 出版日期 | 2009-12-01 |
| 卷号 | 131期号:3页码:271-277 |
| 关键词 | Chromium Grifola frondosa Glucose tolerance Insulin Organ masses |
| ISSN号 | 0163-4984 |
| 文献子类 | Article |
| 英文摘要 | This study was designed to evaluate the effect of administration of chromium-enriched Grifola frondosa (CEGF) in insulin-resistant sucrose-fed mice. Mice were randomly assigned to be unsupplemented (S group) or to receive oral CEGF at a dose of 0.5, 1.0, 2.0, 3.0, 4.0, and 5.0 mg/kg per day chromium. A control group (C) did not consume sucrose and was not supplemented. Sucrose-fed mice had an elevated serum insulin concentration compared with controls and this was significantly lower in sucrose-fed mice that received CEGF (4.0 and 5.0 mg/kg per day chromium), which did not differ from controls. Impaired glucose tolerance in sucrose-fed mice, evidenced by the poor glucose disposal rate following an intraperitoneal glucose tolerance test, was significantly improved in mice receiving CEGF. CEGF is essentially nontoxic at the dose of 4.0 and 5.0 mg/kg per day. These results indicate that CEGF may have potential beneficial effects in insulin-resistant prediabetic conditions.; This study was designed to evaluate the effect of administration of chromium-enriched Grifola frondosa (CEGF) in insulin-resistant sucrose-fed mice. Mice were randomly assigned to be unsupplemented (S group) or to receive oral CEGF at a dose of 0.5, 1.0, 2.0, 3.0, 4.0, and 5.0 mg/kg per day chromium. A control group (C) did not consume sucrose and was not supplemented. Sucrose-fed mice had an elevated serum insulin concentration compared with controls and this was significantly lower in sucrose-fed mice that received CEGF (4.0 and 5.0 mg/kg per day chromium), which did not differ from controls. Impaired glucose tolerance in sucrose-fed mice, evidenced by the poor glucose disposal rate following an intraperitoneal glucose tolerance test, was significantly improved in mice receiving CEGF. CEGF is essentially nontoxic at the dose of 4.0 and 5.0 mg/kg per day. These results indicate that CEGF may have potential beneficial effects in insulin-resistant prediabetic conditions. |
| 学科主题 | 生理心理学/生物心理学 |
| 语种 | 英语 |
| WOS记录号 | WOS:000271396500007 |
| 公开日期 | 2011-08-22 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/5155]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 通讯作者 | J. Y. Guo |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Sichuan Univ, Dept Prosthodont, W China Coll Stomatol, Chengdu 610041, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Qiang,Guo, Jianyou,J. Y. Guo. Activity and Toxicity of Cr(III)-Enriched Grifola frondosa in Insulin-Resistant Mice[J]. BIOLOGICAL TRACE ELEMENT RESEARCH,2009,131(3):271-277. |
| APA | Xu, Qiang,Guo, Jianyou,&J. Y. Guo.(2009).Activity and Toxicity of Cr(III)-Enriched Grifola frondosa in Insulin-Resistant Mice.BIOLOGICAL TRACE ELEMENT RESEARCH,131(3),271-277. |
| MLA | Xu, Qiang,et al."Activity and Toxicity of Cr(III)-Enriched Grifola frondosa in Insulin-Resistant Mice".BIOLOGICAL TRACE ELEMENT RESEARCH 131.3(2009):271-277. |
入库方式： OAI收割
来源：心理研究所
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