Association analysis of NAD(P)H:quinone oxidoreductase gene 609 C/T polymorphism with Alzheimer's disease
文献类型：期刊论文
| 作者 | B. Wang; F. Jin; Y. Xie; Y. Tang; R. Kan; C. Zheng; Z. Yang; L. Wang |
| 刊名 | Neuroscience Letters
 |
| 出版日期 | 2006 |
| 卷号 | 409期号:3页码:179-181 |
| 关键词 | late-onset Alzheimer's disease APOE epsilon 4 NQO1 case-control study Chinese |
| ISSN号 | 0304-3940 |
| 英文摘要 | Alterations of the NAD(P)H:quinone oxidoreductase (NQO1) activity are associated with Alzheimer's disease (AD). A polymorphism consisting of a single nucleotide (C -> T) change at position 609 of NQO1 influences the NQO1 activity. Therefore the NQO1 C609T polymorphism may confer susceptibility for AD developing. To test the hypothesis, we have performed an association study between the NQO1 gene polymorphism C609T and late-onset Alzheimer's disease (LOAD) in Chinese population. Totally 104 LOAD patients and 128 controls were enrolled in our data set. All subjects were genotyped for NQO1 and Apolipoprotein E (APOE). There were no significant differences in NQO1 genotype or allele frequencies between cases and controls. Likewise, with the stratification of APOE epsilon 4 status, no statistical difference was observed between cases and controls. Our findings suggested that this polymorphism might not represent additional genetic risk factor for LOAD. However, the present study cannot exclude NQO1 as a possible candidate for LOAD. Further study in a larger population and biological functional analysis of NQO1 gene is required to verify the role of NQO1 in LOAD. |
| 学科主题 | 医学心理学 |
| 语种 | 英语 |
| 公开日期 | 2011-08-22 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/5199]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 通讯作者 | L. Wang |
| 推荐引用方式 GB/T 7714 | B. Wang,F. Jin,Y. Xie,et al. Association analysis of NAD(P)H:quinone oxidoreductase gene 609 C/T polymorphism with Alzheimer's disease[J]. Neuroscience Letters,2006,409(3):179-181. |
| APA | B. Wang.,F. Jin.,Y. Xie.,Y. Tang.,R. Kan.,...&L. Wang.(2006).Association analysis of NAD(P)H:quinone oxidoreductase gene 609 C/T polymorphism with Alzheimer's disease.Neuroscience Letters,409(3),179-181. |
| MLA | B. Wang,et al."Association analysis of NAD(P)H:quinone oxidoreductase gene 609 C/T polymorphism with Alzheimer's disease".Neuroscience Letters 409.3(2006):179-181. |
入库方式： OAI收割
来源：心理研究所
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