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Common Genetic Variation and the Control of HIV-1 in Humans
文献类型：期刊论文
| 作者 | Fellay, Jacques1; Ge, Dongliang1; Shianna, Kevin V.1,2; Colombo, Sara3; Ledergerber, Bruno4; Cirulli, Elizabeth T.1; Urban, Thomas J.1; Zhang, Kunlin3,5 ; Gumbs, Curtis E.1; Smith, Jason P.2
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| 刊名 | PLOS GENETICS
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| 出版日期 | 2009-12-01 |
| 卷号 | 5期号:12 |
| 关键词 | genome-wide association hla-c host genetics infection aids progression disease polymorphism resistance hcp5 |
| ISSN号 | 1553-7390 |
| 文献子类 | Article |
| 英文摘要 | To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.; To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians. |
| 学科主题 | 遗传学 |
| 语种 | 英语 |
| WOS记录号 | WOS:000273469700041 |
| 公开日期 | 2011-08-22 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/5259]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 通讯作者 | D. B. Goldstein |
| 作者单位 | 1.Duke Univ, Ctr Human Genome Variat, Duke Inst Genome Sci & Policy, Durham, NC 27706 USA 2.Duke Univ, Genom Anal Facil, Duke Inst Genome Sci & Policy, Durham, NC USA 3.Univ Lausanne, Inst Microbiol, Lausanne, Switzerland 4.Univ Zurich, Univ Hosp, Div Infect Dis & Hosp Epidemiol, Zurich, Switzerland 5.Chinese Acad Sci, Inst Psychol, Behav Genet Ctr, Beijing 100101, Peoples R China 6.Vita Salute San Raffaele Univ & Diagnost & Ric Sa, Clin Infect Dis, Milan, Italy 7.UCL, Res Dept Infect & Populat Hlth, London, England 8.Univ Cattolica Sacro Cuore, Inst Clin Infect Dis, I-00168 Rome, Italy 9.Kings Coll London, Acad Dept HIV GUM, Weston Educ Ctr, Guys Hosp, London WC2R 2LS, England 10.Kings Coll London, Acad Dept HIV GUM, Weston Educ Ctr, Kings Hosp, London WC2R 2LS, England |
| 推荐引用方式 GB/T 7714 | Fellay, Jacques,Ge, Dongliang,Shianna, Kevin V.,et al. Common Genetic Variation and the Control of HIV-1 in Humans[J]. PLOS GENETICS,2009,5(12). |
| APA | Fellay, Jacques.,Ge, Dongliang.,Shianna, Kevin V..,Colombo, Sara.,Ledergerber, Bruno.,...&D. B. Goldstein.(2009).Common Genetic Variation and the Control of HIV-1 in Humans.PLOS GENETICS,5(12). |
| MLA | Fellay, Jacques,et al."Common Genetic Variation and the Control of HIV-1 in Humans".PLOS GENETICS 5.12(2009). |
入库方式： OAI收割
来源：心理研究所
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