Converging signal on ERK1/2 activity regulates group I mGluR-mediated Arc transcription
文献类型：期刊论文
| 作者 | Wang, Yan1,2,3,4; Zheng, Fei1,2; Zhou, Xianju1,2; Sun, Zhongsheng3 ; Wang, Hongbing1,2; Z. Sun; H.Wang
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| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2009-08-21 |
| 卷号 | 460期号:1页码:36-40 |
| 关键词 | Arc NMDA receptor L-Type voltage-gated calcium channel Group1 metabotropic glutamate receptors Transcription ERK1/2 |
| ISSN号 | 0304-3940 |
| 文献子类 | Article |
| 英文摘要 | The expression of Arc is tightly coupled to synaptic activities. Recent studies suggested the functional relevance of Arc translation in group I metabotropic glutamate receptor (mGluR)-mediated long-term depression. The present study investigated the transcription-dependent changes of Arc in response to the activation of group I mGluR by (RS)-3,5-dihydroxyphenylglycine (DHPG) in cultured cortical neurons. The increase in Arc mRNA did not require de nova protein synthesis, indicating that Arc is an immediate early gene upon DHPG stimulation. We further examined the major pathways involved in group I mGluR signaling, and found that DHPG-induced Arc up-regulation depended on CaMK, PLC, and ERK1/2 activity. Moreover, the activity of NMDA receptors, but not L-type voltage gated calcium channels (L-VGCC), was required for Arc transcription. Interestingly, blocking CaMK, PLC, and NMDAR, but not L-VGCC, suppressed DHPG-stimulated ERK1/2 activation. These data suggest the central role of ERK1/2 in group I mGluR-mediated Arc transcription.; The expression of Arc is tightly coupled to synaptic activities. Recent studies suggested the functional relevance of Arc translation in group I metabotropic glutamate receptor (mGluR)-mediated long-term depression. The present study investigated the transcription-dependent changes of Arc in response to the activation of group I mGluR by (RS)-3,5-dihydroxyphenylglycine (DHPG) in cultured cortical neurons. The increase in Arc mRNA did not require de nova protein synthesis, indicating that Arc is an immediate early gene upon DHPG stimulation. We further examined the major pathways involved in group I mGluR signaling, and found that DHPG-induced Arc up-regulation depended on CaMK, PLC, and ERK1/2 activity. Moreover, the activity of NMDA receptors, but not L-type voltage gated calcium channels (L-VGCC), was required for Arc transcription. Interestingly, blocking CaMK, PLC, and NMDAR, but not L-VGCC, suppressed DHPG-stimulated ERK1/2 activation. These data suggest the central role of ERK1/2 in group I mGluR-mediated Arc transcription. (C) 2009 Elsevier Ireland Ltd. All rights reserved. |
| 学科主题 | 遗传学 |
| 语种 | 英语 |
| WOS记录号 | WOS:000267633400008 |
| 公开日期 | 2011-08-22 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/5275]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 通讯作者 | Z. Sun; H.Wang |
| 作者单位 | 1.Michigan State Univ, Dept Physiol, E Lansing, MI 48824 USA 2.Michigan State Univ, Neurosci Program, E Lansing, MI 48824 USA 3.Chinese Acad Sci, Inst Psychol, Behav Genet Ctr, Beijing 100101, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yan,Zheng, Fei,Zhou, Xianju,et al. Converging signal on ERK1/2 activity regulates group I mGluR-mediated Arc transcription[J]. NEUROSCIENCE LETTERS,2009,460(1):36-40. |
| APA | Wang, Yan.,Zheng, Fei.,Zhou, Xianju.,Sun, Zhongsheng.,Wang, Hongbing.,...&H.Wang.(2009).Converging signal on ERK1/2 activity regulates group I mGluR-mediated Arc transcription.NEUROSCIENCE LETTERS,460(1),36-40. |
| MLA | Wang, Yan,et al."Converging signal on ERK1/2 activity regulates group I mGluR-mediated Arc transcription".NEUROSCIENCE LETTERS 460.1(2009):36-40. |
入库方式： OAI收割
来源：心理研究所
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