Effects of scopolamine and physostigmine on acquisition of morphine-treated rats in Morris water maze performance
文献类型：期刊论文
| 作者 | Zheng, XG; Li, XW; Yang, XY; Sui, N; Zheng XiGeng |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2002-05-01 |
| 卷号 | 23期号:5页码:477-480 |
| 关键词 | morphine acquisition scopolamine physostigmine Morris water maze |
| ISSN号 | 1671-4083 |
| 文献子类 | Article |
| 英文摘要 | AIM: To investigate effects of morphine on acquisition process of rats a nd interactions of opioid and cholinergic systems by Morris water maze performance.METHODS: Morris water maze was used to measure the latency of rats with drug s treatment to find the covert platform.RESULTS: Chronic morphine administration (10 mg/kg) impaired the acquisition process of rats in Morris water maze task. Appreciable difference was identified with morphine 10 mg/k g group compared with morphine 3 mg/kg group. Co-administration of morphine (10 mg/kg) and scopolamine (3 mg/kg) aggravated acquisition impairment induced by morphine 1 0 mg/kg or scopolamine alone, though scopolamine itself induced no salient changes in acquisition capabilities of rats. In addition, physostigmine (0.1 mg/kg) could appreciably attenuate morphine-induced acquisition impairment.CONCLUSION: Morphine 10 mg/kg evidently impaired acquisition process of rats. There was a close relationship between the acquisition capabilities of morphine-treated rats and the functions of cholinergic system.; AIM: To investigate effects of morphine on acquisition process of rats and interactions of opioid and cholinergic systems by Morris water maze performance. METHODS: Morris water maze was used to measure the latency of ruts With drugs treatment to find the covert platform. RESULTS: Chronic morphine administration (10 mg/kg) impaired the acquisition process of rats in Morris water maze task. Appreciable difference was identified With morphine 10 mg/kg group compared with morphine 3 mg/kg group. Co-administration of morphine ( 10 mg/kg) and scopolamine (3 mg/kg) aggravated acquisition impairment induced by morphine 10 mg/kg or scopolamine alone, though scopolamine itself induced no salient changes in acquisition capabilities of rats. In addition, physostigmine (0.1 mg/kg) could appreciably attenuate morphine-induced acquisition impairment. CONCLUSION: Morphine 10 mg/kg evidently impaired acquisition process of rats. There was a close relationship between the acquisition capabilities of morphine-treated rats and the functions of cholinergic system. |
| 学科主题 | 生理心理学/生物心理学 |
| 语种 | 英语 |
| WOS记录号 | WOS:000175399400016 |
| 公开日期 | 2011-08-22 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/5363]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 通讯作者 | Zheng XiGeng |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Brain & Behav Res Ctr, Beijing 100101, Peoples R China 2.Henan Univ, Dept Psychol, Kaifeng 475001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, XG,Li, XW,Yang, XY,et al. Effects of scopolamine and physostigmine on acquisition of morphine-treated rats in Morris water maze performance[J]. ACTA PHARMACOLOGICA SINICA,2002,23(5):477-480. |
| APA | Zheng, XG,Li, XW,Yang, XY,Sui, N,&Zheng XiGeng.(2002).Effects of scopolamine and physostigmine on acquisition of morphine-treated rats in Morris water maze performance.ACTA PHARMACOLOGICA SINICA,23(5),477-480. |
| MLA | Zheng, XG,et al."Effects of scopolamine and physostigmine on acquisition of morphine-treated rats in Morris water maze performance".ACTA PHARMACOLOGICA SINICA 23.5(2002):477-480. |
入库方式： OAI收割
来源：心理研究所
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