Enhanced visuomotor associative learning following stimulation of alpha(2A)-adrenoceptors in the ventral prefrontal cortex in monkeys
文献类型：期刊论文
| 作者 | Wang, M; Tang, ZX; Li, BM; Bao-Ming Li |
| 刊名 | BRAIN RESEARCH
 |
| 出版日期 | 2004-10-22 |
| 卷号 | 1024期号:1-2页码:176-182 |
| 关键词 | guanfacine alpha(2A)-adrenoceptor ventral prefrontal cortex visuomotor associative learning monkey |
| ISSN号 | 0006-8993 |
| 文献子类 | Article |
| 英文摘要 | The present study investigated the effect of locally infused guanfacine, an α2A-adrenergic agonist, into the ventral prefrontal cortex (PFv) on visuomotor associative learning. Two monkeys were well trained on a two-problem visuomotor associative task: the monkeys performed movement A if presented with a circle pattern, or movement B if presented with a triangle pattern. For learning of new visuomotor associations, the monkeys were presented with a new set of four patterns in each and every daily session, two of which instructed movement A and the other two movement B. Bilaterally infused guanfacine (2.5 μg/μl; 3 μl on each side) improved the monkeys' ability to learn new visuomotor associations: trials and errors to learning criterion of 90% correct decreased significantly. The monkeys showed an enhanced capability to use win–stay/lose–shift strategy on ‘repeat trials’ and change–stay/change–shift strategy on ‘change trials.’ The present results indicate that α2A-adrenoceptor in the PFv is involved in regulating visuomotor associative learning.; The present study investigated the effect of locally infused guanfacine, an alpha(2A)-adrenergic agonist, into the ventral prefrontal cortex (PFv) on visuomotor associative learning. Two monkeys were well trained on a two-problem visuomotor associative task: the monkeys performed movement A if presented with a circle pattern, or movement B if presented with a triangle pattern. For learning of new visuomotor associations, the monkeys were presented with a new set of four patterns in each and every daily session, two of which instructed movement A and the other two movement B. Bilaterally infused guanfacine (2.5 mug/mul; 3 mul on each side) improved the monkeys' ability to learn new visuomotor associations: trials and errors to learning criterion of 90% correct decreased significantly. The monkeys showed an enhanced capability to use win-stay/lose-shift strategy on `repeat trials' and change-stay/change-shift strategy on 'change trials.' The present results indicate that alpha(2A)-adrenoceptor in the PFv is involved in regulating visuomotor associative learning. (C) 2004 Elsevier B.V. All rights reserved. |
| 学科主题 | 生理心理学/生物心理学 |
| 语种 | 英语 |
| WOS记录号 | WOS:000224664800019 |
| 公开日期 | 2011-08-22 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/5379]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 通讯作者 | Bao-Ming Li |
| 作者单位 | 1.Fudan Univ, Inst Neurobiol, Lab Higher Brain Funct, Shanghai 200433, Peoples R China 2.Guangxi Normal Univ, Coll Life Sci, Guilin 541004, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, M,Tang, ZX,Li, BM,et al. Enhanced visuomotor associative learning following stimulation of alpha(2A)-adrenoceptors in the ventral prefrontal cortex in monkeys[J]. BRAIN RESEARCH,2004,1024(1-2):176-182. |
| APA | Wang, M,Tang, ZX,Li, BM,&Bao-Ming Li.(2004).Enhanced visuomotor associative learning following stimulation of alpha(2A)-adrenoceptors in the ventral prefrontal cortex in monkeys.BRAIN RESEARCH,1024(1-2),176-182. |
| MLA | Wang, M,et al."Enhanced visuomotor associative learning following stimulation of alpha(2A)-adrenoceptors in the ventral prefrontal cortex in monkeys".BRAIN RESEARCH 1024.1-2(2004):176-182. |
入库方式： OAI收割
来源：心理研究所
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