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Functional MRI in attention-deficit hyperactivity disorder: Evidence for hypofrontality

文献类型：期刊论文

作者Zang, YF; Jin, Z; Weng, XC; Zhang, L; Zeng, YW; Yang, L; Wang, YF; Seidman, LJ; Faraone, SV; Yu-Feng Wang
刊名BRAIN & DEVELOPMENT
出版日期2005-12-01
卷号27期号:8页码:544-550
关键词attention-deficit hyperactivity disorder functional magnetic resonance imaging Stroop effect hypofrontality methylphenidate compensation
ISSN号0387-7604
文献子类Article
英文摘要Using event-related functional magnetic resonance imaging to study the Stroop, effect on both behavioral and brain activation of ADHD children off or on methylphenidate (MPH). Nine ADHD boys (aged 9.8-14.5 years) and 9 age-matched normal controls were included. A Stroop-like paradigm was used. AFNI (Analysis of Functional Neurolmaging) and its Deconvolution Analysis were used in a descriptive comparison between ADHD and control groups. (1) Both behavioral reaction time and brain activation showed Stroop effect in controls but neither was found in ADHD children off MPH. When MPH was administered, the Stroop effect tended to appear. (2) The activation volume (AV) of prefrontal cortex (PFC) in both the neutral (NC) and interference conditions (IQ in ADHD children off MPH was smaller than in controls. AV of anterior cingulate cortex in the IC in ADHD children off MPH was smaller than that in controls, but was similar in the NC to that in controls. AV of the basal ganglia, insula and cerebellum was also smaller in the IC, but was larger in the NC for ADHD children off MPH compared with controls. These findings are consistent with prior findings of hypofrontality in ADHD children and implicate a compensatory network including basal ganglia, insula and cerebellum for relative lower cognitive load tasks.; Using event-related functional magnetic resonance imaging to study the Stroop, effect on both behavioral and brain activation of ADHD children off or on methylphenidate (MPH). Nine ADHD boys (aged 9.8-14.5 years) and 9 age-matched normal controls were included. A Stroop-like paradigm was used. AFNI (Analysis of Functional Neurolmaging) and its Deconvolution Analysis were used in a descriptive comparison between ADHD and control groups. (1) Both behavioral reaction time and brain activation showed Stroop effect in controls but neither was found in ADHD children off MPH. When MPH was administered, the Stroop effect tended to appear. (2) The activation volume (AV) of prefrontal cortex (PFC) in both the neutral (NC) and interference conditions (IQ in ADHD children off MPH was smaller than in controls. AV of anterior cingulate cortex in the IC in ADHD children off MPH was smaller than that in controls, but was similar in the NC to that in controls. AV of the basal ganglia, insula and cerebellum was also smaller in the IC, but was larger in the NC for ADHD children off MPH compared with controls. These findings are consistent with prior findings of hypofrontality in ADHD children and implicate a compensatory network including basal ganglia, insula and cerebellum for relative lower cognitive load tasks. (c) 2005 Elsevier B.V. All rights reserved.
学科主题变态心理学
语种英语
WOS记录号WOS:000234199200002
公开日期2011-08-22
源URL[http://ir.psych.ac.cn/handle/311026/5429]  
专题心理研究所_中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Yu-Feng Wang
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
2.306 Hosp, Dept MRI, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Lab Higher Brain Funct, Beijing 100101, Peoples R China
4.Massachusetts Mental Hlth Ctr, Boston, MA 02115 USA
5.Harvard Univ, Sch Med, Dept Psychiat, Cambridge, MA 02138 USA
6.Massachusetts Gen Hosp, Psychiat Serv, Boston, MA 02114 USA
7.Harvard Univ, Inst Psychiat Epidemiol & Genet, Boston, MA 02115 USA
8.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100864, Peoples R China
推荐引用方式
GB/T 7714		 Zang, YF,Jin, Z,Weng, XC,et al. Functional MRI in attention-deficit hyperactivity disorder: Evidence for hypofrontality[J]. BRAIN & DEVELOPMENT,2005,27(8):544-550.
APA Zang, YF.,Jin, Z.,Weng, XC.,Zhang, L.,Zeng, YW.,...&Yu-Feng Wang.(2005).Functional MRI in attention-deficit hyperactivity disorder: Evidence for hypofrontality.BRAIN & DEVELOPMENT,27(8),544-550.
MLA Zang, YF,et al."Functional MRI in attention-deficit hyperactivity disorder: Evidence for hypofrontality".BRAIN & DEVELOPMENT 27.8(2005):544-550.

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来源：心理研究所

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