Heat shock protein72 protects hippocampal neurons from apoptosis induced by chronic psychological stress
文献类型：期刊论文
| 作者 | Yao, Shuqiao; Peng, Min; Zhu, Xiongzhao; Cheng, Ming; Qi, Xiaoli ; SHUQIAO YAO
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| 刊名 | INTERNATIONAL JOURNAL OF NEUROSCIENCE
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| 出版日期 | 2007 |
| 卷号 | 117期号:11页码:1551-1564 |
| 关键词 | apoptosis heat shock stress hippocampus HSP72 psychological stress |
| ISSN号 | 0020-7454 |
| 文献子类 | Article |
| 英文摘要 | When exposed to nonlethal heat stress (i.e., heat shock preconditioning), HSP72 expression increased in the mammalian brain. HSP72 enhance the viability of neurons and decrease TUNEL-positive neurons under several kinds of stress ( e. g., ischemic). Chronic psychological stress is a kind of stress that could cause hippocampal neuron apoptosis. But whether overexpression of HSP72 can decrease TUNEL-positive hippocampal neurons caused by chronic psychological stress is unclear. To investigate the possible protective role of HSP72 in decreasing chronic psychological stress-induced hippocampal neuron apoptosis, this study analyzed HSP72 expression, apoptotic neurons in the hippocampus of mice. Adult mice were divided into four groups unstressed group; chronic psychological stress group; heat shock stress group; heat shock preconditioning plus psychological stress group; receiving no experimental stress, chronic psychological stress, heat shock stress, heat shock preconditioning plus psychological stress separately. Mice were killed after one month, two months, or three months of stress. A three-way ANOVA ( psychological stress x heat shock stress x time) revealed a significant effect of heat shock stress in increasing HSP72 expression, decreasing neuronal apoptosis in hippocampus CA3 region caused by chronic psychological stress, and showed that HSP72 protected hippocampus CA3 neurons from chronic psychological stress.; When exposed to nonlethal heat stress (i.e., heat shock preconditioning), HSP72 expression increased in the mammalian brain. HSP72 enhance the viability of neurons and decrease TUNEL-positive neurons under several kinds of stress ( e. g., ischemic). Chronic psychological stress is a kind of stress that could cause hippocampal neuron apoptosis. But whether overexpression of HSP72 can decrease TUNEL-positive hippocampal neurons caused by chronic psychological stress is unclear. To investigate the possible protective role of HSP72 in decreasing chronic psychological stress-induced hippocampal neuron apoptosis, this study analyzed HSP72 expression, apoptotic neurons in the hippocampus of mice. Adult mice were divided into four groups unstressed group; chronic psychological stress group; heat shock stress group; heat shock preconditioning plus psychological stress group; receiving no experimental stress, chronic psychological stress, heat shock stress, heat shock preconditioning plus psychological stress separately. Mice were killed after one month, two months, or three months of stress. A three-way ANOVA ( psychological stress x heat shock stress x time) revealed a significant effect of heat shock stress in increasing HSP72 expression, decreasing neuronal apoptosis in hippocampus CA3 region caused by chronic psychological stress, and showed that HSP72 protected hippocampus CA3 neurons from chronic psychological stress. |
| 学科主题 | 健康心理学 |
| 语种 | 英语 |
| WOS记录号 | WOS:000250304000005 |
| 公开日期 | 2011-08-22 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/5443]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 通讯作者 | SHUQIAO YAO |
| 作者单位 | 1.Ctr S Univ Changasha, 2nd Xianya Hosp, Med Psychol Res, Changsha 410011, Peoples R China 2.Inst Psychol, Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yao, Shuqiao,Peng, Min,Zhu, Xiongzhao,et al. Heat shock protein72 protects hippocampal neurons from apoptosis induced by chronic psychological stress[J]. INTERNATIONAL JOURNAL OF NEUROSCIENCE,2007,117(11):1551-1564. |
| APA | Yao, Shuqiao,Peng, Min,Zhu, Xiongzhao,Cheng, Ming,Qi, Xiaoli,&SHUQIAO YAO.(2007).Heat shock protein72 protects hippocampal neurons from apoptosis induced by chronic psychological stress.INTERNATIONAL JOURNAL OF NEUROSCIENCE,117(11),1551-1564. |
| MLA | Yao, Shuqiao,et al."Heat shock protein72 protects hippocampal neurons from apoptosis induced by chronic psychological stress".INTERNATIONAL JOURNAL OF NEUROSCIENCE 117.11(2007):1551-1564. |
入库方式： OAI收割
来源：心理研究所
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