HERC1 polymorphisms: population-specific variations in haplotype composition
文献类型：期刊论文
| 作者 | Yuasa, Isao1; Umetsu, Kazuo2; Nishimukai, Hiroaki3; Fukumori, Yasuo4; Harihara, Shinji5; Saitou, Naruya6; Jin, Feng7 ; Chattopadhyay, Prasanta K.8; Henke, Lotte9; Henke, Juergen9
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| 刊名 | CELL BIOCHEMISTRY AND FUNCTION
 |
| 出版日期 | 2009-08-01 |
| 卷号 | 27期号:6页码:402-405 |
| ISSN号 | 0263-6484 |
| 关键词 | genotyping haplotype HERC1 single nucleotide polymorphism population study |
| 文献子类 | Article |
| 英文摘要 | Human HERC1 is one of six HERC proteins and may play an important role in intracellular membrane trafficking. The human HERC1 gene is suggested to have been affected by local positive selection. To assess the global frequency distributions of coding and non-coding single nucleotide polymorphisms (SNPs) in the HERC1 gene, we developed a new simultaneous genotyping method for four SNPs, and applied this method to investigate 1213 individuals from 12 global populations. The results confirmed remarked differences in the allele and haplotype frequencies between East Asian and non-East Asian populations. One of the three common haplotypes observed was found to be characteristic of East Asians, who showed a relatively uniform distribution of haplotypes. Information on haplotypes would be useful for testing the function of polymorphisms in the HERC1 gene. This is the first study to investigate the distribution of HERC1 polymorphisms in various populations.; Human HERC1 is one of six HERC proteins and may play an important role in intracellular membrane trafficking. The human HERC1 gene is suggested to have been affected by local positive selection. To assess the global frequency distributions of coding and non-coding single nucleotide polymorphisms (SNPs) in the HERC1 gene, we developed a new simultaneous genotyping method for four SNPs, and applied this method to investigate 1213 individuals from 12 global populations. The results confirmed remarked differences in the allele and haplotype frequencies between East Asian and non-East Asian populations. One of the three common haplotypes observed was found to be characteristic of East Asians, who showed a relatively uniform distribution of haplotypes. Information on haplotypes would be useful for testing the function of polymorphisms in the HERC1 gene. This is the first study to investigate the distribution of HERC1 polymorphisms in various populations. Copyright (C) 2009 John Wiley & Sons, Ltd. |
| 学科主题 | 遗传学 |
| 语种 | 英语 |
| WOS记录号 | WOS:000269384800012 |
| 公开日期 | 2011-08-22 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/5445]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 通讯作者 | Isao Yuasa |
| 作者单位 | 1.Tottori Univ, Fac Med, Div Legal Med, Yonago, Tottori 6838503, Japan 2.Yamagata Univ, Fac Med, Dept Forens Med, Yamagata 990, Japan 3.Ehime Univ, Sch Med, Div Legal Med, Matsuyama, Ehime 790, Japan 4.Osaka Red Cross Blood Ctr, Osaka, Japan 5.Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Tokyo 113, Japan 6.Natl Inst Genet, Div Populat Genet, Mishima, Shizuoka 411, Japan 7.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 8.Amity Inst Forens Sci, New Delhi, India 9.Inst Blutgrp Forsch, Cologne, Germany |
| 推荐引用方式 GB/T 7714 | Yuasa, Isao,Umetsu, Kazuo,Nishimukai, Hiroaki,et al. HERC1 polymorphisms: population-specific variations in haplotype composition[J]. CELL BIOCHEMISTRY AND FUNCTION,2009,27(6):402-405. |
| APA | Yuasa, Isao.,Umetsu, Kazuo.,Nishimukai, Hiroaki.,Fukumori, Yasuo.,Harihara, Shinji.,...&Isao Yuasa.(2009).HERC1 polymorphisms: population-specific variations in haplotype composition.CELL BIOCHEMISTRY AND FUNCTION,27(6),402-405. |
| MLA | Yuasa, Isao,et al."HERC1 polymorphisms: population-specific variations in haplotype composition".CELL BIOCHEMISTRY AND FUNCTION 27.6(2009):402-405. |
入库方式： OAI收割
来源：心理研究所
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