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Mismatch negativity to the patient's own name in chronic disorders of consciousness

文献类型：期刊论文

作者Qin, Pengmin1; Di, Haibo2; Yan, Xiaodan1; Yuc, Senming3; Yu, Dan3; Laureys, Steven4,5; Weng, Xuchu1; X. C. Weng
刊名NEUROSCIENCE LETTERS
出版日期2008-12-19
卷号448期号:1页码:24-28
关键词Mismatch negativity Disorders of consciousness Vegetative state Minimally conscious state Own name
ISSN号0304-3940
文献子类Article
英文摘要Previous studies implicated potential value of mismatch negativity (MMN) in predicting recovery of consciousness in patients with disorders of consciousness (DOC). We have adopted a novel MMN evoked by subject's own name (SON), a self-referential stimulus thought to be powerful in evoking residual brain activity, and examined the correlation between the MMN and recovery of consciousness in patients with chronic (> 1 month) DOC. Twelve patients and 12 age-matched healthy controls were investigated. The patients were diagnosed as coma (n = 4). vegetative state (VS, n = 6), and minimally conscious state (MCS, n = 2), mainly based on the JFK Coma Recovery Scale-Revised. The SON-evoked MMN (SON-MMN) was present in seven patients. Critically, the presence of SON-MMN was significantly correlated with recovery of consciousness. While four of the five patients (three VS and two coma) showing SON-MMN changed to MCS 3 months later, the rest of the patients (three VS and two coma) without SON-MMN failed to show any clinical improvement. Our study thus illustrates that the subject's own name is effective in evoking MMN in patients with DOC, and that SON-MMN has potential prognostic values in predicting recovery of consciousness.; Previous studies implicated potential value of mismatch negativity (MMN) in predicting recovery of consciousness in patients with disorders of consciousness (DOC). We have adopted a novel MMN evoked by subject's own name (SON), a self-referential stimulus thought to be powerful in evoking residual brain activity, and examined the correlation between the MMN and recovery of consciousness in patients with chronic (> 1 month) DOC. Twelve patients and 12 age-matched healthy controls were investigated. The patients were diagnosed as coma (n = 4). vegetative state (VS, n = 6), and minimally conscious state (MCS, n = 2), mainly based on the JFK Coma Recovery Scale-Revised. The SON-evoked MMN (SON-MMN) was present in seven patients. Critically, the presence of SON-MMN was significantly correlated with recovery of consciousness. While four of the five patients (three VS and two coma) showing SON-MMN changed to MCS 3 months later, the rest of the patients (three VS and two coma) without SON-MMN failed to show any clinical improvement. Our study thus illustrates that the subject's own name is effective in evoking MMN in patients with DOC, and that SON-MMN has potential prognostic values in predicting recovery of consciousness. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
学科主题认知神经科学
语种英语
WOS记录号WOS:000261553800006
公开日期2011-08-22
源URL[http://ir.psych.ac.cn/handle/311026/5543]  
专题心理研究所_中国科学院心理研究所回溯数据库(1956-2010)
通讯作者X. C. Weng
作者单位1.Chinese Acad Sci, Inst Psychol, Lab Higher Brain Funct, Beijing 100101, Peoples R China
2.Hangzhou Normal Univ, Hangzhou, Zhejiang, Peoples R China
3.Wujing Hosp Hangzhou City, Rehabil Ctr Brain Damage, Hangzhou, Zhejiang, Peoples R China
4.Univ Liege, Coma Sci Grp, Cyclotron Res Ctr, Liege, Belgium
5.Univ Liege, Dept Neurol, Liege, Belgium
推荐引用方式
GB/T 7714		 Qin, Pengmin,Di, Haibo,Yan, Xiaodan,et al. Mismatch negativity to the patient's own name in chronic disorders of consciousness[J]. NEUROSCIENCE LETTERS,2008,448(1):24-28.
APA Qin, Pengmin.,Di, Haibo.,Yan, Xiaodan.,Yuc, Senming.,Yu, Dan.,...&X. C. Weng.(2008).Mismatch negativity to the patient's own name in chronic disorders of consciousness.NEUROSCIENCE LETTERS,448(1),24-28.
MLA Qin, Pengmin,et al."Mismatch negativity to the patient's own name in chronic disorders of consciousness".NEUROSCIENCE LETTERS 448.1(2008):24-28.

入库方式： OAI收割

来源：心理研究所

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