Neurological soft signs as candidate endophenotypes for schizophrenia: A shooting star or a Northern star?
文献类型：期刊论文
| 作者 | Chan, Raymond C. K.1,2,3 ; Gottesman, Irving I.4,5; R. C. K. Chan
|
| 刊名 | NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
 |
| 出版日期 | 2008-07-01 |
| 卷号 | 32期号:5页码:957-971 |
| 关键词 | neurological soft signs endophenotype schizophrenia |
| ISSN号 | 0149-7634 |
| 文献子类 | Review |
| 英文摘要 | The crucial role of neurological indicators in schizophrenia has been recognized as among the "target features" that encompass the idea that genetic and non-genetic processes lead to neurointegrative defects later manifested in neurocognitive systems. In addition, aberrant neurological indicators have also been suggested as potential endophenotypes in schizophrenia. In the current paper, we review evidence for the utility of quantifiable neurological soft signs as potential endophenotypes for schizophrenia spectrum disorders. We start by defining endophenotypes and justifying their utility. We highlight the key criteria that must be met for an endophenotype to be useful and assess the extent to which the manifestations of neurological soft signs meet these criteria. Finally, we recommend areas in which additional research should be done to further elucidate the potential use of neurological soft signs for schizophrenia research.; The crucial role of neurological indicators in schizophrenia has been recognized as among the "target features" that encompass the idea that genetic and non-genetic processes lead to neurointegrative defects later manifested in neurocognitive systems. In addition, aberrant neurological indicators have also been suggested as potential endophenotypes in schizophrenia. In the current paper, we review evidence for the utility of quantifiable neurological soft signs as potential endophenotypes for schizophrenia spectrum disorders. We start by defining endophenotypes and justifying their utility. We highlight the key criteria that must be met for an endophenotype to be useful and assess the extent to which the manifestations of neurological soft signs meet these criteria. Finally, we recommend areas in which additional research should be done to further elucidate the potential use of neurological soft signs for schizophrenia research. (C) 2008 Elsevier Ltd. All rights reserved. |
| 学科主题 | 精神病学 |
| 语种 | 英语 |
| WOS记录号 | WOS:000257276700005 |
| 公开日期 | 2011-08-22 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/5587]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 通讯作者 | R. C. K. Chan |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 3.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China 4.Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA 5.Univ Minnesota, Dept Psychol, Minneapolis, MN 55455 USA |
| 推荐引用方式 GB/T 7714 | Chan, Raymond C. K.,Gottesman, Irving I.,R. C. K. Chan. Neurological soft signs as candidate endophenotypes for schizophrenia: A shooting star or a Northern star?[J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,2008,32(5):957-971. |
| APA | Chan, Raymond C. K.,Gottesman, Irving I.,&R. C. K. Chan.(2008).Neurological soft signs as candidate endophenotypes for schizophrenia: A shooting star or a Northern star?.NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,32(5),957-971. |
| MLA | Chan, Raymond C. K.,et al."Neurological soft signs as candidate endophenotypes for schizophrenia: A shooting star or a Northern star?".NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 32.5(2008):957-971. |
入库方式： OAI收割
来源：心理研究所
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