中国科学院机构知识库网格
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Novelty-seeking behavior and stress-induced locomotion in rats of juvenile period differentially related to morphine place conditioning in their adulthood

文献类型:期刊论文

作者Zheng, XG; Tan, BP; Luo, XJ; Xu, W; Yang, XY; Sui, N; N. Sui
刊名BEHAVIOURAL PROCESSES
出版日期2004-01-30
卷号65期号:1页码:15-23
关键词development morphine novelty seeking place conditioning stress
ISSN号0376-6357
文献子类Article
英文摘要The relationship between motor responses in a novel environment and susceptibility to place conditioning effect of psychostimulants has been reported in adult rats. However, it is in question whether this correlation could be generalized to motor activity in rats of juvenile period and place conditioning effect in their adulthood for narcotic morphine. In the present study, we tested locomotor activity in an arena open-field and the subsequent novelty-seeking behavior after adaptation process in juvenile rats (P42) and morphine (2 mg/kg) place conditioning effect 56 days later in the same rats' adulthood (P98). Our results showed that rats with high response to novelty (HRN) spent more prolonged duration in the drug-paired compartment in the place conditioning test compared with their low response counterparts (LRN), with the latter group no salient change on this measure. Moreover, rats with high response to the open-field test (HRS) expressed equally elevated duration in drug-paired side relative to their low response counterparts (LRS). The present research demonstrated that novelty-seeking behavior and locomotor activity in the open-field in rats of juvenile period differentially related to morphine place conditioning in their adulthood, with slow acquisition of morphine place conditioning effect in LRN animals; The relationship between motor responses in a novel environment and susceptibility to place conditioning effect of psychostimulants has been reported in adult rats. However, it is in question whether this correlation could be generalized to motor activity in rats of juvenile period and place conditioning effect in their adulthood for narcotic morphine. In the present study, we tested locomotor activity in an arena open-field and the subsequent novelty-seeking behavior after adaptation process in juvenile rats (P42) and morphine (2 mg/kg) place conditioning effect 56 days later in the same rats' adulthood (P98). Our results showed that rats with high response to novelty (HRN) spent more prolonged duration in the drug-paired compartment in the place conditioning test compared with their low response counterparts (LRN), with the latter group no salient change on this measure. Moreover, rats with high response to the open-field test (HRS) expressed equally elevated duration in drug-paired side relative to their low response counterparts (LRS). The present research demonstrated that novelty-seeking behavior and locomotor activity in the open-field in rats of juvenile period differentially related to morphine place conditioning in their adulthood, with slow acquisition of morphine place conditioning effect in LRN animals. (C) 2003 Elsevier B.V. All rights reserved.
学科主题医学心理学
语种英语
WOS记录号WOS:000188861400003
公开日期2011-08-22
源URL[http://ir.psych.ac.cn/handle/311026/5593]  
专题心理研究所_中国科学院心理研究所回溯数据库(1956-2010)
通讯作者N. Sui
作者单位Acad Sinica, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Zheng, XG,Tan, BP,Luo, XJ,et al. Novelty-seeking behavior and stress-induced locomotion in rats of juvenile period differentially related to morphine place conditioning in their adulthood[J]. BEHAVIOURAL PROCESSES,2004,65(1):15-23.
APA Zheng, XG.,Tan, BP.,Luo, XJ.,Xu, W.,Yang, XY.,...&N. Sui.(2004).Novelty-seeking behavior and stress-induced locomotion in rats of juvenile period differentially related to morphine place conditioning in their adulthood.BEHAVIOURAL PROCESSES,65(1),15-23.
MLA Zheng, XG,et al."Novelty-seeking behavior and stress-induced locomotion in rats of juvenile period differentially related to morphine place conditioning in their adulthood".BEHAVIOURAL PROCESSES 65.1(2004):15-23.

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来源:心理研究所

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