Opposite effects of MK-801 on the expression of food and morphine-induced conditioned place preference in rats
文献类型：期刊论文
| 作者 | Li, YH ; Zheng, XG; Bai, YJ; Yang, XY; Sui, N; N. Sui
|
| 刊名 | JOURNAL OF PSYCHOPHARMACOLOGY
 |
| 出版日期 | 2006 |
| 卷号 | 20期号:1页码:40-46 |
| 关键词 | MK-801 morphine food expression of CPP craving |
| ISSN号 | 0269-8811 |
| 文献子类 | Article |
| 英文摘要 | Behavioural studies have provided strong evidence for common substrates in the rewards of natural and addictive substances, but it is still unclear whether there is a common glutamatergic NMDA receptor mechanism involved in the processing of reward for both. The present study was designed to investigate the effects of MK-801 (0.1mg/kg) on the expression of place preference conditioned with food and morphine (5.0mg/kg) in rats. The data indicates that MK-801 potentiates the expression of food-induced conditioned place preference (CPP) but retards that of morphine CPP. It also demonstrates that the opposite effects of MK-801 on food and morphine CPP expression were caused neither by hyperactivity nor by the impairment of memory retrieval. These results suggest that MK-801 enhances food craving and inhibits morphine craving in rats, and that the roles of glutamatergic NMDA receptor mechanisms in the reward processing of natural reinforcers and addictive drugs may be dissociable.; Behavioural studies have provided strong evidence for common substrates in the rewards of natural and addictive substances, but it is still unclear whether there is a common glutamatergic NMDA receptor mechanism involved in the processing of reward for both. The present study was designed to investigate the effects of MK-801 (0.1 mg/kg) on the expression of place preference conditioned with food and morphine (5.0 mg/kg) in rats. The data indicates that MK-801 potentiates the expression of food-induced conditioned place preference (CPP) but retards that of morphine CPP. It also demonstrates that the opposite effects of MK-801 on food and morphine CPP expression were caused neither by hyperactivity nor by the impairment of memory retrieval. These results suggest that MK-801 enhances food craving and inhibits morphine craving in rats, and that the roles of glutamatergic NMDA receptor mechanisms in the reward processing of natural reinforcers and addictive drugs may be dissociable. |
| 学科主题 | 医学心理学 |
| 语种 | 英语 |
| WOS记录号 | WOS:000235451200006 |
| 公开日期 | 2011-08-22 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/5601]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 通讯作者 | N. Sui |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 2.Chinese Acad Sci, Lab Mental Hlth, Beijing, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, YH,Zheng, XG,Bai, YJ,et al. Opposite effects of MK-801 on the expression of food and morphine-induced conditioned place preference in rats[J]. JOURNAL OF PSYCHOPHARMACOLOGY,2006,20(1):40-46. |
| APA | Li, YH,Zheng, XG,Bai, YJ,Yang, XY,Sui, N,&N. Sui.(2006).Opposite effects of MK-801 on the expression of food and morphine-induced conditioned place preference in rats.JOURNAL OF PSYCHOPHARMACOLOGY,20(1),40-46. |
| MLA | Li, YH,et al."Opposite effects of MK-801 on the expression of food and morphine-induced conditioned place preference in rats".JOURNAL OF PSYCHOPHARMACOLOGY 20.1(2006):40-46. |
入库方式： OAI收割
来源：心理研究所
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