The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE epsilon 4 allele increases the risk of late-onset Alzheimer disease
文献类型：期刊论文
| 作者 | Wang, Binbin; Jin, Feng ; Yang, Ze; Lu, Zeping; Kan, Rui; Li, Shu; Zheng, Chenguang; Wang, Li; L. Wang
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| 刊名 | JOURNAL OF MOLECULAR NEUROSCIENCE
 |
| 出版日期 | 2006 |
| 卷号 | 30期号:3页码:267-271 |
| 关键词 | late-onset Alzheimer's disease angiotensin-converting enzyme ACE apolipoprotein E polymorphism Chinese |
| ISSN号 | 0895-8696 |
| 文献子类 | Article |
| 英文摘要 | Several studies have shown that a common insertion (I)/deletion (D) polymorphism of angiotensin-converting enzyme (ACE) gene may confer an increased risk of late-onset Alzheimer disease (LOAD). However, the result has not been replicated by all studies. In order to clarify the role of the polymorphism for the occurrence of LOAD in Chinese and the possibility of a synergistic effect with the apolipoprotein E allele 4 on the risk of Alzheimer disease, we examined the ACE and APOE genotypes in a Chinese sample consisting of 104 sporadic LOAD patients and 128 healthy controls. An obvious difference of allelic and genotypic distributions of ACE I/D polymorphism between cases and controls was observed (chi2 = 6.61, df = 2, p = 0.037 by genotype; chi2 = 4.67, df = 1, p = 0.031 by allele). And ACE I allele carriers showed an increased risk for LOAD developing (chi2 = 6.59, df = 1, p =0.01, OR = 2.91, 95% CI 1.25-6.77). After stratifying by APOE epsilon 4 status, the increased LOAD risks associated with I allele carriers only in the APOE epsilon 4 noncarriers was seen (chi2 = 4.12, df = 1, p = 0.042). Logistic regression analysis of total subjects demonstrated a more than sevenfold increase in the risk of developing LOAD in subjects carrying both the ACE I allele and the APOE epsilon 4 (OR = 7.39, 95% CI 2.50-21.89, p < 0.001). Our data revealed that ACE I/D polymorphism is considered to be an additional risk factor, which has strong synergistic interaction with APOE epsilon 4 on the risk of LOAD.; Several studies have shown that a common insertion (I)/deletion (D) polymorphism of angiotensin-converting enzyme (ACE) gene may confer an increased risk of late-onset Alzheimer disease (LOAD). However, the result has not been replicated by all studies. In order to clarify the role of the polymorphism. for the occurrence of LOAD in Chinese and the possibility of a synergistic effect with the apolipoprotein E allele 4 on the risk of Alzheimer disease, we examined the ACE and APOE genotypes in a Chinese sample consisting of 104 sporadic LOAD patients and 128 healthy controls. An obvious difference of allelic and genotypic distributions of ACE I/D polymorphism between cases and controls was observed (chi(2) = 6.61, df = 2, p = 0.037 by genotype; chi(2) = 4.67, df = 1, p = 0.031 by allele). And ACE I allele carriers showed an increased risk for LOAD developing (chi(2) = 6.59, df = 1, p = 0.01, OR = 2.91,95% CI 1.25-6.77). After stratifying by APOE epsilon 4 status, the increased LOAD risks associated with I allele carriers only in the APOE epsilon 4 noncarriers was seen (chi(2) = 4.12, df = 1, p = 0.042). Logistic regression analysis of total subjects demonstrated a more than sevenfold increase in the risk of developing LOAD in subjects carrying both the ACE I allele and the APOE epsilon 4 (OR = 7.39,95% CI 2.50-21.89, p < 0.001). Our data revealed that ACE I/D polymorphism is considered to be an additional risk factor, which has strong synergistic interaction with APOE epsilon 4 on the risk of LOAD. |
| 学科主题 | 神经病学 |
| 语种 | 英语 |
| WOS记录号 | WOS:000243782200002 |
| 公开日期 | 2011-08-22 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/5773]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 通讯作者 | L. Wang |
| 作者单位 | 1.Chinese Acad Sci, Inst Genet & Dev Biol, Ctr Human & Anim Genet, Beijing, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Res Lab Behav Biol, Beijing, Peoples R China 4.Beijing Hosp, Minist Hlth, Inst Geriatr, Med Genet Lab, Beijing, Peoples R China 5.Jiangbin Hosp, Nanning, Guangxi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Binbin,Jin, Feng,Yang, Ze,et al. The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE epsilon 4 allele increases the risk of late-onset Alzheimer disease[J]. JOURNAL OF MOLECULAR NEUROSCIENCE,2006,30(3):267-271. |
| APA | Wang, Binbin.,Jin, Feng.,Yang, Ze.,Lu, Zeping.,Kan, Rui.,...&L. Wang.(2006).The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE epsilon 4 allele increases the risk of late-onset Alzheimer disease.JOURNAL OF MOLECULAR NEUROSCIENCE,30(3),267-271. |
| MLA | Wang, Binbin,et al."The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE epsilon 4 allele increases the risk of late-onset Alzheimer disease".JOURNAL OF MOLECULAR NEUROSCIENCE 30.3(2006):267-271. |
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来源：心理研究所
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