Thirsty heroin addicts show different fMRI activations when exposed to water-related and drug-related cues
文献类型：期刊论文
| 作者 | Xiao, ZW; Lee, T; Zhang, JX; Wu, QL; Wu, RH; Weng, XC; Hu, XP; Z. W. Xiao |
| 刊名 | DRUG AND ALCOHOL DEPENDENCE
 |
| 出版日期 | 2006-06-28 |
| 卷号 | 83期号:2页码:157-162 |
| 关键词 | addiction craving drug-dependence heroin opiate functional MRI |
| ISSN号 | 0376-8716 |
| 文献子类 | Article |
| 英文摘要 | Relapse to drug use is frequently preceded or caused by craving, an intense desire for drug. Advances in functional brain imaging techniques make it possible to directly investigate this special mental state in vivo and non-invasively. Extant imaging studies on craving have been mostly on cocaine which is the dominant drug abused in the U.S. Employing functional MRI, we examined substance specificity of the neural circuitry underlying craving for heroin. Heroin is the primary drug abused in south-east Asia and has, particularly, become a serious social problem for China in recent years. Following abstinence from water and drug, 14 active heroin addicts (all male, mean age 33.2 years, average drug use history 7.1 years) underwent scanning inside a 1.5T Philips MR scanner during exposure to water-related, drug-related, and neutral cues. Water-related cues elicited anterior cingulate activation (Brodmann's area BA 32/24). Drug-related cues activated bilateral inferior frontal cortex (BA 44/45), confirming the critical role of prefrontal cortex in drug craving. Results suggest heroin craving may involve different neural substrates than do desire from basic physiological drives, such as thirst. As the first fMRI study of heroin craving, our study adds to the scant but much-needed brain imaging literature on heroin addiction.; Relapse to drug use is frequently preceded or caused by craving, an intense desire for drug. Advances in functional brain imaging techniques make it possible to directly investigate this special mental state in vivo and non-invasively. Extant imaging studies on craving have been mostly on cocaine which is the dominant drug abused in the U.S. Employing functional MRI, we examined substance specificity of the neural circuitry underlying craving for heroin. Heroin is the primary drug abused in south-east Asia and has, particularly, become a serious social problem for China in recent years. Following abstinence from water and drug, 14 active heroin addicts (all male, mean age 33.2 years, average drug use history 7.1 years) underwent scanning inside a 1.5T Philips MR scanner during exposure to water-related, drug-related, and neutral cues. Water-related cues elicited anterior cingulate activation (Brodmann's area BA 32/24). Drug-related cues activated bilateral inferior frontal cortex (BA 44/45), confirming the critical role of prefromal cortex in drug craving. Results suggest heroin craving may involve different neural substrates than do desire from basic physiological drives, such as thirst. As the first fMRI study of heroin craving, our study adds to the scant but much-needed brain imaging literature on heroin addiction. (c) 2005 Elsevier Ireland Ltd. All rights reserved. |
| 学科主题 | 医学心理学 |
| 语种 | 英语 |
| WOS记录号 | WOS:000238702100008 |
| 公开日期 | 2011-08-22 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/5817]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 通讯作者 | Z. W. Xiao |
| 作者单位 | 1.Shantou Univ, Guangdong Key Lab Med Mol Imaging, Affiliated Hosp 1, Sch Med, Shantou, Peoples R China 2.Univ Hong Kong, Neuropsychol Lab, Hong Kong, Hong Kong, Peoples R China 3.MacLehose Med Rehabil Ctr, Inst Clin Neuropsychol, Hong Kong, Hong Kong, Peoples R China 4.Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China 5.Chinese Acad Sci, Lab Higher Brain Funct, Inst Psychol, Beijing, Peoples R China 6.Georgia Inst Technol, Coulter Dept Biomed Engn, Atlanta, GA 30332 USA 7.Emory Univ, Atlanta, GA 30322 USA |
| 推荐引用方式 GB/T 7714 | Xiao, ZW,Lee, T,Zhang, JX,et al. Thirsty heroin addicts show different fMRI activations when exposed to water-related and drug-related cues[J]. DRUG AND ALCOHOL DEPENDENCE,2006,83(2):157-162. |
| APA | Xiao, ZW.,Lee, T.,Zhang, JX.,Wu, QL.,Wu, RH.,...&Z. W. Xiao.(2006).Thirsty heroin addicts show different fMRI activations when exposed to water-related and drug-related cues.DRUG AND ALCOHOL DEPENDENCE,83(2),157-162. |
| MLA | Xiao, ZW,et al."Thirsty heroin addicts show different fMRI activations when exposed to water-related and drug-related cues".DRUG AND ALCOHOL DEPENDENCE 83.2(2006):157-162. |
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来源：心理研究所
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