Modulation of medial prefrontal cortical dopamine on the expression of morphine-induced sensitization in rats
文献类型：会议论文
| 作者 | X. J. Luo; X. G. Zheng; Y. H. Li; J. Liu; B. P. Tan |
| 出版日期 | 2004 |
| 会议日期 | 2004 |
| 会议地点 | Beijing |
| 页码 | 285-285 |
| 英文摘要 | Rats were administered morphine (5mg•kg-1, i.p.) or saline for seven days and tested with intra-mPFC (medial prefrontal cortex) microinjection of D1 receptor agonist SKF38393 (0-2.0 μg/side), or D1 receptor antagonist SCH23390 (0-1.0 μg/side). SKF38393 dose-dependently suppressed the expression of morphine sensitization while SCH23390 enhanced the locomotor response to morphine. But for saline-pretreated rats, the same doses of SKF38393 and SCH23390 had little influence on their locomotor activity. These results indicate that morphine-induced hypersensitization of mPFC dopamine may be a neural substrate mediating morphine sensitization, and further suggest the inhibitive effects of mPFC dopamine on the expression of morphine sensitization. |
| 资助机构 | IUPsyS |
| 学科主题 | 医学心理学 |
| 语种 | 英语 |
| WOS记录号 | WOS:000226118002598 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/6341]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 推荐引用方式 GB/T 7714 | X. J. Luo,X. G. Zheng,Y. H. Li,et al. Modulation of medial prefrontal cortical dopamine on the expression of morphine-induced sensitization in rats[C]. 见:. Beijing. 2004. |
入库方式： OAI收割
来源：心理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。