Adolescent chronic apomorphine treatment impairs latent inhibition and reduces prefrontal cortex mGluR5 receptor expression in adult rats
文献类型：期刊论文
| 作者 | Shao, Feng1; Han, Xiao1; Li, Nanxin1,2; Wang, Weiwen3 ; Wang WW(王玮文)
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| 刊名 | EUROPEAN JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 2010-12-15 |
| 卷号 | 649期号:1-3页码:202-205 |
| 关键词 | Adolescent Apomorphine Dopamine Glutamate Latent inhibition Schizophrenia |
| ISSN号 | 0014-2999 |
| 文献子类 | Article |
| 英文摘要 | Adolescence is a critical period for neurodevelopment Disturbances during adolescence have significant deleterious effects on brain function and animal behavior Latent inhibition refers to the process in which pre exposure to a stimulus retards subsequent conditioning of this stimulus Previous studies demonstrate that adolescent social isolation significantly impairs latent inhibition and disrupts cortical dopamine and glutamate neurotransmission However It remains elusive whether dopamine agonism during adolescence has any effect on latent inhibition or cortical glutamate activity In the current study adolescent Wistar rats were subjected to chronic dopamine agonist apomorphine treatment (1 mg/kg for 14 days) Latent inhibition and metabotropic glutamate receptor 5 (mGluR5) expression levels were examined at adulthood The results demonstrate that adolescent chronic apomorphine treatment severely impairs latent inhibition and decreases mGluR5 receptor expression in the prefrontal cortex This study provides further evidence that pubertal dopaminergic deviation could result in schizophrenic-like behavioral and neurochemical abnormalities (C) 2010 Elsevier B V All rights reserved |
| 学科主题 | 生理心理学/生物心理学 |
| 资助项目 | 一室林文娟课题组 |
| 语种 | 英语 |
| WOS记录号 | WOS:000284294000027 |
| 公开日期 | 2011-11-14 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/7019]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 通讯作者 | Wang WW(王玮文) |
| 作者单位 | 1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China 2.Yale Univ, Dept Psychol, Div Mol Psychiat, New Haven, CT 06508 USA 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shao, Feng,Han, Xiao,Li, Nanxin,et al. Adolescent chronic apomorphine treatment impairs latent inhibition and reduces prefrontal cortex mGluR5 receptor expression in adult rats[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2010,649(1-3):202-205. |
| APA | Shao, Feng,Han, Xiao,Li, Nanxin,Wang, Weiwen,&王玮文.(2010).Adolescent chronic apomorphine treatment impairs latent inhibition and reduces prefrontal cortex mGluR5 receptor expression in adult rats.EUROPEAN JOURNAL OF PHARMACOLOGY,649(1-3),202-205. |
| MLA | Shao, Feng,et al."Adolescent chronic apomorphine treatment impairs latent inhibition and reduces prefrontal cortex mGluR5 receptor expression in adult rats".EUROPEAN JOURNAL OF PHARMACOLOGY 649.1-3(2010):202-205. |
入库方式： OAI收割
来源：心理研究所
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