中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Increased thermal and mechanical nociceptive thresholds in rats with depressive-like behaviors

文献类型:期刊论文

作者Shi, Miao2,3; Qi, Wei-Jing1; Gao, Ge1; Wang, Jin-Yan1; Luo, Fei1,2,3; Wang JY(王锦琰)
刊名BRAIN RESEARCH
出版日期2010-09-24
卷号1353页码:225-233
关键词Unpredictable chronic mild stress Depression Hot plate test Neuropathic pain Von Frey filament Allodynia
ISSN号0006-8993
DOI10.1016/j.brainres.2010.07.023
产权排序1
文献子类Article
英文摘要

Clinical observations suggest that depressed patients were less sensitive to experimental pain than healthy subjects. However, few animal studies are reported concerning the association of depression and pain. The purpose of this study was to investigate the effects of unpredictable chronic mild stress (UCMS) induced depression on the perceived intensity of painful stimulation in rats. We measured the thermal and mechanical paw withdrawal thresholds (PWT) of normal and spinal nerve ligated (SNL) rats using hot plate test and von Frey test, respectively. The results showed that rats exposed to UCMS exhibited significantly higher thermal and mechanical pain thresholds in comparison to the non-depressed controls. In particular, the PWT of the SNL group was restored to nearly normal level after three weeks of UCMS, and even comparable to that of the control group. These results strongly suggest that the depressed subjects have decreased sensitivity to externally applied noxious stimulation, which is consistent with our previous findings. (C) 2010 Elsevier B.V. All rights reserved.

学科主题医学心理学
资助项目一室罗非课题组
语种英语
WOS记录号WOS:000282419500023
公开日期2011-11-14
源URL[http://ir.psych.ac.cn/handle/311026/7023]  
专题心理研究所_中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Wang JY(王锦琰)
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Peking Univ Hlth Sci, Neurosci Res Inst, Beijing, Peoples R China
3.Peking Univ Hlth Sci, Dept Neurobiol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Shi, Miao,Qi, Wei-Jing,Gao, Ge,et al. Increased thermal and mechanical nociceptive thresholds in rats with depressive-like behaviors[J]. BRAIN RESEARCH,2010,1353:225-233.
APA Shi, Miao,Qi, Wei-Jing,Gao, Ge,Wang, Jin-Yan,Luo, Fei,&王锦琰.(2010).Increased thermal and mechanical nociceptive thresholds in rats with depressive-like behaviors.BRAIN RESEARCH,1353,225-233.
MLA Shi, Miao,et al."Increased thermal and mechanical nociceptive thresholds in rats with depressive-like behaviors".BRAIN RESEARCH 1353(2010):225-233.

入库方式: OAI收割

来源:心理研究所

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