Coexistence of Anhedonia and anxiety-independent increased novelty-seeking behavior in the chronic mild stress model of depression
文献类型：期刊论文
| 作者 | Li, Y.1,2 ; Zheng, X.1; Liang, J.1; Peng, Y.1,2; Zheng XG(郑希耕); Zheng, Xigeng; Liang, Jing
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| 刊名 | BEHAVIOURAL PROCESSES
 |
| 出版日期 | 2010-03-01 |
| 卷号 | 83期号:3页码:331-339 |
| ISSN号 | 0376-6357 |
| 关键词 | Anhedonia Anxiety Chronic mild stress Depression Novelty-seeking |
| 文献子类 | Article |
| 英文摘要 | Previous research demonstrated excessive decreases in reward sensitivity and increases in harm avoidance in depressed individuals. These results straightly lead to a hypothesis that depressed patients should avoid novelty or express reduced novelty-seeking behavior. Nevertheless, literature in this regard is inconsistent. Furthermore, whether the potentially altered novelty-associated behavior is dependent on changed anxiety/fear or related to altered goal-directed approaching tendency is unclear. Here, we tested novel object-approaching behavior in a free-exploration paradigm in chronic mild stress (CMS)-induced anhedonic and stress-resistant rats respectively. Other CMS-induced, emotional behaviors were also examined in a battery of behavioral tests including novel cage, exploration, locomotor activity and elevated plus maze (EPM). We found that compared with controls, stress-resistant rats who consistently showed lower anxiety level in EPM (time in open arms) and, open-field (OF) test (time in central area) showed no sign of enhanced novel object approaching behavior. To the contrary, the anhedonic ones who did not express any sign of reduced anxiety showed paradoxically intensified novelty-approaching behavior. We concluded that reduced anxiety would not necessarily lead to enhanced novelty-seeking behavior; anhedonia coexists with anxiety-independent, increased novelty-seeking behavior. The salient paradox of coexistence of anhedonia and increased novelty-seeking behavior was critically discussed. (C) 2010 Elsevier B.V. All rights reserved. |
| 学科主题 | 医学心理学 |
| 资助项目 | 一室郑希耕课题组 |
| 语种 | 英语 |
| WOS记录号 | WOS:000276666600015 |
| 公开日期 | 2011-11-14 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/7045]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 通讯作者 | Zheng XG(郑希耕); Zheng, Xigeng |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Lab Expt Clin Psychol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Y.,Zheng, X.,Liang, J.,et al. Coexistence of Anhedonia and anxiety-independent increased novelty-seeking behavior in the chronic mild stress model of depression[J]. BEHAVIOURAL PROCESSES,2010,83(3):331-339. |
| APA | Li, Y..,Zheng, X..,Liang, J..,Peng, Y..,郑希耕.,...&Liang, Jing.(2010).Coexistence of Anhedonia and anxiety-independent increased novelty-seeking behavior in the chronic mild stress model of depression.BEHAVIOURAL PROCESSES,83(3),331-339. |
| MLA | Li, Y.,et al."Coexistence of Anhedonia and anxiety-independent increased novelty-seeking behavior in the chronic mild stress model of depression".BEHAVIOURAL PROCESSES 83.3(2010):331-339. |
入库方式： OAI收割
来源：心理研究所
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