Effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways in rats
文献类型：期刊论文
| 作者 | Wang, Ning1 ; Zhang, Yang2; Wang, Jin-Yan1; Gao, Ge1; Luo, Fei1; Luo F(罗非)
|
| 刊名 | NEUROSCIENCE BULLETIN
 |
| 出版日期 | 2010-06-01 |
| 卷号 | 26期号:3页码:188-196 |
| 关键词 | anesthesia laser, multiple single-unit recording |
| ISSN号 | 1673-7067 |
| 文献子类 | Article |
| 英文摘要 | Objective To investigate the effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways. Methods Laser stimulation was employed to evoke nociceptive responses in rats under awake or anesthetic conditions. Pain-related neuronal activities were simultaneously recorded from the primary somatosensory cortex (SI), ventral posterolateral thalamus (VPL), anterior cingulate cortex (ACC), and medial dorsal thalamus (MD) with 4 eight-wire microelectrode arrays. Results Compared with the awake state, pentobarbital anesthesia significantly suppressed the neural activities induced by noxious laser stimulation. Meanwhile, the pain-evoked changes in the neuronal correlations between cortex and thalamus were suppressed in both medial and lateral pain pathways. In addition, the spontaneous firing rates in all the 4 areas were altered (including inhibition and excitation) under the condition of anesthesia. Conclusion The nociceptive processing in the brain can be dramatically changed by anesthesia, which indicates that there are considerable differences in the brain activities between awake and anesthetized states. It is better to employ awake animals for recording neural activity when investigating the sensory coding mechanisms, especially pain coding, in order to obtain data that precisely reflect the physiological state. |
| 学科主题 | 健康心理学 |
| 资助项目 | 一室罗非课题组 |
| 语种 | 英语 |
| WOS记录号 | WOS:000295724200002 |
| 公开日期 | 2011-12-02 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/7227]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 通讯作者 | Luo F(罗非) |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Ning,Zhang, Yang,Wang, Jin-Yan,et al. Effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways in rats[J]. NEUROSCIENCE BULLETIN,2010,26(3):188-196. |
| APA | Wang, Ning,Zhang, Yang,Wang, Jin-Yan,Gao, Ge,Luo, Fei,&罗非.(2010).Effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways in rats.NEUROSCIENCE BULLETIN,26(3),188-196. |
| MLA | Wang, Ning,et al."Effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways in rats".NEUROSCIENCE BULLETIN 26.3(2010):188-196. |
入库方式： OAI收割
来源：心理研究所
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