The effect of depression on the thermal nociceptive thresholds in rats with spontaneous pain
文献类型：期刊论文
| 作者 | Su, Yuan-Lin1,2 ; Wang, Ning1; Gao, Ge1; Wang, Jin-Yan1; Luo, Fei1; Luo F(罗非)
|
| 刊名 | NEUROSCIENCE BULLETIN
 |
| 出版日期 | 2010-12-01 |
| 卷号 | 26期号:6页码:429-436 |
| 关键词 | depression evoked pain formalin olfactory bulbectomy thermal stimulation |
| ISSN号 | 1673-7067 |
| 文献子类 | Article |
| 英文摘要 | Objective Recently, there has been growing interest in the interaction between depressive disorders and pain. The purpose of this study was to examine whether depression would lead to a decreased sensitivity to noxious stimuli in rats with spontaneous pain. Methods The olfactory bulbectomized rats were used as a model of depression. The depression-like behaviors were assessed by open field test and changes in body weight. Formalin solution was injected into the rat hindpaw to produce ongoing pain. Noxious thermal stimuli were applied onto the hindpaw contralateral to formalin injection, and the withdrawal thresholds were measured. Results In non-depressive rats, the formalin-treated paw developed hypoalgesia to noxious stimuli while the contralateral paw was not affected. The depressive rats, however, showed a significantly lower sensitivity to noxious thermal stimulus, represented as higher withdrawal thresholds of the contralateral paw, when compared to the non-depressive rats. Conclusion These results demonstrate that depression can alleviate the stimulus-evoked pain even in the context of formalin inflammatory pain, consistent with the previous clinical observations that patients suffering from both depression and persistent pain have decreased sensitivities to noxious experimental stimuli. |
| 学科主题 | 健康心理学 |
| 资助项目 | 一室罗非课题组 |
| 语种 | 英语 |
| WOS记录号 | WOS:000295725800001 |
| 公开日期 | 2011-12-02 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/7229]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 通讯作者 | Luo F(罗非) |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Su, Yuan-Lin,Wang, Ning,Gao, Ge,et al. The effect of depression on the thermal nociceptive thresholds in rats with spontaneous pain[J]. NEUROSCIENCE BULLETIN,2010,26(6):429-436. |
| APA | Su, Yuan-Lin,Wang, Ning,Gao, Ge,Wang, Jin-Yan,Luo, Fei,&罗非.(2010).The effect of depression on the thermal nociceptive thresholds in rats with spontaneous pain.NEUROSCIENCE BULLETIN,26(6),429-436. |
| MLA | Su, Yuan-Lin,et al."The effect of depression on the thermal nociceptive thresholds in rats with spontaneous pain".NEUROSCIENCE BULLETIN 26.6(2010):429-436. |
入库方式： OAI收割
来源：心理研究所
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