Peri-adolescence isolation rearing alters social behavior and nociception in rats
文献类型：期刊论文
| 作者 | Meng, Qingxuan1; Li, Nanxin1,2; Han, Xiao1; Shao, Feng1; Wang, Weiwen3 ; Wang WW(王玮文); Feng Shao
|
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2010-08-09 |
| 卷号 | 480期号:1页码:25-29 |
| 关键词 | Adolescent Anxiety Open field Pain sensitivity Social interaction Social isolation |
| ISSN号 | 0304-3940 |
| 文献子类 | Article |
| 英文摘要 | Social isolation results in fundamental behavioral abnormalities in rodents which models certain neuropsychiatric disorders such as schizophrenia. However, the developmental stage that is most vulnerable to social isolation is largely unknown. In the present study, we subjected weaning rats to a four-week peri-adolescence isolation rearing (PAIR) and then returned them to social rearing for an additional four weeks until adulthood. Open field locomotion, social interaction behavior, and acute pain sensitivity were examined at different time points. PAIR rats showed moderate hyperactivity towards a novel environment, an anxiogenic-like behavioral profile, and increased aggression and social interaction behavior, the last three of which could be restored by re-socialization procedure. In addition, PAIR animals showed significantly reduced pain sensitivity even after the re-socialization period. In summary, this study advances the use of pen-adolescent isolation rearing as an animal model to study neurodevelopmental manipulation induced behavioral abnormalities. (C) 2010 Elsevier Ireland Ltd. All rights reserved. |
| 学科主题 | 生理心理学/生物心理学 |
| 资助项目 | 一室林文娟课题组 |
| 语种 | 英语 |
| WOS记录号 | WOS:000280471400007 |
| 公开日期 | 2011-12-02 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/7237]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 通讯作者 | Wang WW(王玮文); Feng Shao |
| 作者单位 | 1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China 2.Yale Univ, Div Mol Psychiat, Dept Psychol, New Haven, CT 06508 USA 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Meng, Qingxuan,Li, Nanxin,Han, Xiao,et al. Peri-adolescence isolation rearing alters social behavior and nociception in rats[J]. NEUROSCIENCE LETTERS,2010,480(1):25-29. |
| APA | Meng, Qingxuan.,Li, Nanxin.,Han, Xiao.,Shao, Feng.,Wang, Weiwen.,...&Feng Shao.(2010).Peri-adolescence isolation rearing alters social behavior and nociception in rats.NEUROSCIENCE LETTERS,480(1),25-29. |
| MLA | Meng, Qingxuan,et al."Peri-adolescence isolation rearing alters social behavior and nociception in rats".NEUROSCIENCE LETTERS 480.1(2010):25-29. |
入库方式： OAI收割
来源：心理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。