The differential effects of depression on evoked and spontaneous pain behaviors in olfactory bulbectomized rats
文献类型：期刊论文
| 作者 | Wang, Wei1 ; Qi, Wei-Jing1,2; Xu, Yang1; Wang, Jin-Yan1; Luo, Fei1; Wang JY(王锦琰); Luo F(罗非)
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| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2010-03-19 |
| 卷号 | 472期号:2页码:143-147 |
| 关键词 | Depression Evoked pain Formalin Olfactory bulbectomy |
| ISSN号 | 0304-3940 |
| 文献子类 | Article |
| 英文摘要 | Although it has been accepted that depression and pain are common comorbidities, their interaction is not fully understood. The current study was aimed to investigate the effects of depression on both evoked pain behavior (thermal-induced nociception) and spontaneous pain behavior (formalin pain) using an olfactory bulbectomy (OB) rat model of depression. Emotional behaviors were assessed by open field and Morris water maze tests. The results showed that the depressed rats exhibited stronger tolerance to noxious thermal stimulation compared to non-depressed animals. In contrast, the spontaneous nociceptive behaviors induced by formalin injection were significantly enhanced in the OB rats in comparison to control rats. These results demonstrated that depression can have differential effects on stimulus-evoked pain and spontaneous pain, with alleviation in the former while aggravation in the latter. The present study has confirmed our previous findings that depression can inhibit evoked pain but facilitate spontaneous pain, and provides evidence that the OB depression model is a feasible model for studying the relationship between depression and pain. (C) 2010 Elsevier Ireland Ltd. All rights reserved. |
| 学科主题 | 认知神经科学 |
| 资助项目 | 一室罗非课题组 |
| 语种 | 英语 |
| WOS记录号 | WOS:000276300300014 |
| 公开日期 | 2011-12-02 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/7241]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 通讯作者 | Wang JY(王锦琰); Luo F(罗非) |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Wei,Qi, Wei-Jing,Xu, Yang,et al. The differential effects of depression on evoked and spontaneous pain behaviors in olfactory bulbectomized rats[J]. NEUROSCIENCE LETTERS,2010,472(2):143-147. |
| APA | Wang, Wei.,Qi, Wei-Jing.,Xu, Yang.,Wang, Jin-Yan.,Luo, Fei.,...&罗非.(2010).The differential effects of depression on evoked and spontaneous pain behaviors in olfactory bulbectomized rats.NEUROSCIENCE LETTERS,472(2),143-147. |
| MLA | Wang, Wei,et al."The differential effects of depression on evoked and spontaneous pain behaviors in olfactory bulbectomized rats".NEUROSCIENCE LETTERS 472.2(2010):143-147. |
入库方式： OAI收割
来源：心理研究所
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