i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study
文献类型：期刊论文
| 作者 | Zhang, Kunlin ; Cui, Sijia; Chang, Suhua; Zhang, Liuyan; Wang, Jing; Wang J(王晶)
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| 刊名 | NUCLEIC ACIDS RESEARCH
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| 出版日期 | 2010-07-01 |
| 卷号 | 38期号:suppl 2页码:W90-W95 |
| ISSN号 | 0305-1048 |
| 文献子类 | Article |
| 英文摘要 | Genome-wide association study (GWAS) is nowadays widely used to identify genes involved in human complex disease. The standard GWAS analysis examines SNPs/genes independently and identifies only a number of the most significant SNPs. It ignores the combined effect of weaker SNPs/genes, which leads to difficulties to explore biological function and mechanism from a systems point of view. Although gene set enrichment analysis (GSEA) has been introduced to GWAS to overcome these limitations by identifying the correlation between pathways/gene sets and traits, the heavy dependence on genotype data, which is not easily available for most published GWAS investigations, has led to limited application of it. In order to perform GSEA on a simple list of GWAS SNP P-values, we implemented GSEA by using SNP label permutation. We further improved GSEA (i-GSEA) by focusing on pathways/gene sets with high proportion of significant genes. To provide researchers an open platform to analyze GWAS data, we developed the i-GSEA4GWAS (improved GSEA for GWAS) web server. i-GSEA4GWAS implements the i-GSEA approach and aims to provide new insights in complex disease studies. i-GSEA4GWAS is freely available at http://gsea4gwas.psych.ac.cn/. |
| 学科主题 | 生理心理学/生物心理学 |
| 资助项目 | 一室王晶课题组 |
| 语种 | 英语 |
| WOS记录号 | WOS:000284148900016 |
| 公开日期 | 2011-12-02 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/7245]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 通讯作者 | Wang J(王晶) |
| 作者单位 | Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Kunlin,Cui, Sijia,Chang, Suhua,et al. i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study[J]. NUCLEIC ACIDS RESEARCH,2010,38(suppl 2):W90-W95. |
| APA | Zhang, Kunlin,Cui, Sijia,Chang, Suhua,Zhang, Liuyan,Wang, Jing,&王晶.(2010).i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study.NUCLEIC ACIDS RESEARCH,38(suppl 2),W90-W95. |
| MLA | Zhang, Kunlin,et al."i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study".NUCLEIC ACIDS RESEARCH 38.suppl 2(2010):W90-W95. |
入库方式： OAI收割
来源：心理研究所
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