中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Functional inactivation of dorsal medial striatum afters behavioral flexibility and recognition process in mice

文献类型:期刊论文

作者Qiao, Yanhua1,2; Wang, Xingyue1,2; Ma, Lian1,2; Li, Shengguang1,2; Liang, Jing1,2
刊名PHYSIOLOGY & BEHAVIOR
出版日期2017-10-01
卷号179期号:0页码:467-477
ISSN号0031-9384
关键词Dorsomedial striatum Neuronal inactivation Recognition process Reversal learning Tetanus toxin light chain
DOI10.1016/j.physbeh.2017.07.026
文献子类Article
英文摘要

Deficits in behavioral flexibility and recognition memory are commonly observed in mental illnesses and neurodegenerative diseases. Abnormality of the striatum has been implicated in an association with the pathology of these diseases. However, the exact roles of striatal heterogeneous structures in these cognitive functions are still unknown. In the present study, we investigated the effects of suppressing neuronal activity in the dorsomedial striatum (DMStr) and nucleus accumbens core (NAcC) on reversal learning and novelty recognition in mice. In addition, the locomotor activity, anxiety-like behavior and social interaction were analyzed. Neuronal inactivation was performed by expressing lentivirus-mediated tetanus toxin (TeNT) in the target regions. The results showed that reversal learning was facilitated by neuronal inactivation in the DMStr but not the NAcC, which was attributable to accelerated extinction of acquired strategy but not to impaired memory retention. Furthermore, mice with NAcC inactivation spent more time exploring a novel object than a familiar one, comparable to control mice. In contrast, mice with DMStr inactivation exhibited no preference to a novel environment during the novel object or place recognition test. The DMStr mice also exhibited decreased anxiety level. No phenotypic effect was observed in the locomotion or social interaction in mice with either DMStr or NAcC inactivation. Altogether, these findings suggest that the DMStr but not the ventral area of the striatum plays a crucial role in learning and memory by coordinating spatial exploration as well as mediating information updating.

WOS关键词NUCLEUS-ACCUMBENS CORE ; OBJECT RECOGNITION ; PREFRONTAL CORTEX ; VISUAL-DISCRIMINATION ; SYNAPTIC-TRANSMISSION ; DORSOMEDIAL STRIATUM ; PARKINSONS-DISEASE ; ANTERIOR CINGULATE ; SELECTIVE LESIONS ; RECEPTOR AGONIST
WOS研究方向Psychology ; Behavioral Sciences
语种英语
WOS记录号WOS:000411533000061
资助机构National Natural Science Foundation of China(31571108) ; National Key Basic Research Program of China(2015CB553501) ; Beijing Natural Science Foundation(5162023)
源URL[http://ir.psych.ac.cn/handle/311026/21929]  
专题心理研究所_中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Qiao, Yanhua,Wang, Xingyue,Ma, Lian,et al. Functional inactivation of dorsal medial striatum afters behavioral flexibility and recognition process in mice[J]. PHYSIOLOGY & BEHAVIOR,2017,179(0):467-477.
APA Qiao, Yanhua,Wang, Xingyue,Ma, Lian,Li, Shengguang,&Liang, Jing.(2017).Functional inactivation of dorsal medial striatum afters behavioral flexibility and recognition process in mice.PHYSIOLOGY & BEHAVIOR,179(0),467-477.
MLA Qiao, Yanhua,et al."Functional inactivation of dorsal medial striatum afters behavioral flexibility and recognition process in mice".PHYSIOLOGY & BEHAVIOR 179.0(2017):467-477.

入库方式: OAI收割

来源:心理研究所

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