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The Influence of Expectation on Nondeceptive Placebo and Nocebo Effects

文献类型：期刊论文

作者Wei, Hua1,2,3; Zhou, Lili1,2; Zhang, Huijuan1,2,3; Chen, Jie4; Lu, Xuejing1,2; Hu, Li1,2,3,4; Jie Chen; Xuejing Lu
刊名PAIN RESEARCH & MANAGEMENT
出版日期2018
期号0页码:0
ISSN号1203-6765
DOI10.1155/2018/8459429
产权排序1
文献子类Article
英文摘要Nondeceptive placebo has demonstrated its efficiency in clinical practice. Although the underlying mechanisms are still unclear, nondeceptive placebo effect and nondeceptive nocebo effect may be mediated by expectation. To examine the extent to which expectation influences these effects, the present study compared nondeceptive placebo and nocebo effects with different expectation levels. Seventy-two healthy female participants underwent a standard conditioning procedure to establish placebo and nocebo effects. Sequentially, participants were randomized to one of the four experimental groups-baseline (BL), no expectation intervention (NoEI), expectation increasing (EI), and expectation decreasing (ED) groups, to receive either no intervention or interventions through different verbal suggestions that modulated their expectation. Placebo and nocebo effects were established in all four groups after the conditioning phase. However, after disclosing the placebo and nocebo, the analgesic and the hyperalgesic effects only persisted in the EI group, when compared with the BL group. Our results provide evidence highlighting the critical role of increased expectation in nondeceptive placebo and nocebo effects. The finding suggests that open-label placebo or nocebo per se might be insufficient to induce strong analgesic or hyperalgesic response and sheds insights into administrating open-label placebo and avoiding open-label nocebo in clinical practice.
WOS关键词RANDOMIZED CONTROLLED-TRIAL ; IRRITABLE-BOWEL-SYNDROME ; INFORMED-CONSENT ; PAIN PERCEPTION ; BRAIN ACTIVITY ; ANALGESIA ; RESPONSES ; MECHANISMS ; EXPERIENCE ; ANXIETY
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:000428908900001
资助机构National Natural Science Foundation of China(31471082 ; Chongqing Research Program of Basic Research and Frontier Technology(cstc2015jcyjBX0050) ; Scientific Foundation Project of Institute of Psychology, Chinese Academy of Sciences(Y6CX021008 ; Cognition and Human Behavior Key Laboratory of Hunan Province, Hunan Normal University(CBL201605) ; 31671141 ; Y6CX281007) ; 31701000 ; 31771240)
源URL[http://ir.psych.ac.cn/handle/311026/25701]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Jie Chen; Xuejing Lu
作者单位1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Southwest Univ, Fac Psychol, Chongqing, Peoples R China
4.Hunan Normal Univ, Cognit & Human Behav Key Lab Hunan Prov, Changsha, Hunan, Peoples R China
推荐引用方式
GB/T 7714		 Wei, Hua,Zhou, Lili,Zhang, Huijuan,et al. The Influence of Expectation on Nondeceptive Placebo and Nocebo Effects[J]. PAIN RESEARCH & MANAGEMENT,2018(0):0.
APA Wei, Hua.,Zhou, Lili.,Zhang, Huijuan.,Chen, Jie.,Lu, Xuejing.,...&Xuejing Lu.(2018).The Influence of Expectation on Nondeceptive Placebo and Nocebo Effects.PAIN RESEARCH & MANAGEMENT(0),0.
MLA Wei, Hua,et al."The Influence of Expectation on Nondeceptive Placebo and Nocebo Effects".PAIN RESEARCH & MANAGEMENT .0(2018):0.

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来源：心理研究所

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