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Role of Anterior Intralaminar Nuclei of Thalamus Projections to Dorsomedial Striatum in Incubation of Methamphetamine Craving

文献类型：期刊论文

作者Li, Xuan1,2; Witonsky, Kailyn R.1; Lofaro, Olivia M.1; Surjono, Felicia1; Zhang, Jianjun1,3; Bossert, Jennifer M.1; Shaham, Yavin1
刊名JOURNAL OF NEUROSCIENCE
出版日期2018-02-28
卷号38期号:9页码:2270-2282
关键词anterior intralaminar nuclei of thalamus dorsomedial striatum glutamate methamphetamine relapse retrograde tracing
ISSN号0270-6474
DOI10.1523/JNEUROSCI.2873-17.2018
产权排序3
文献子类Article
英文摘要Relapse to methamphetamine (Meth) seeking progressively increases after withdrawal from drug self-administration (incubation of Meth craving). We previously demonstrated a role of dorsomedial striatum (DMS) dopamine D1 receptors (D1Rs) in this incubation. Here, we studied the role of afferent glutamatergic projections into the DMS and local D1R-glutamate interaction in this incubation in male rats. We first measured projection-specific activation on day 30 relapse test by using cholera toxin b (retrograde tracer) + Fos (activity marker) double-labeling in projection areas. Next, we determined the effect of pharmacological reversible inactivation of lateral or medial anterior intralaminar nuclei of thalamus (AIT-L or AIT-M) on incubated Meth seeking on withdrawal day 30. We then used an anatomical asymmetrical disconnection procedure to determine whether an interaction between AIT-L -> DMS glutamatergic projections and postsynaptic DMS D1Rs contributes to incubated Meth seeking. We also determined the effect of unilateral inactivation of AIT-L and D1R blockade of DMS on incubated Meth seeking, and the effect of contralateral disconnection of AIT-L -> DMS projections on nonincubated Meth seeking on withdrawal day 1. Incubated Meth seeking was associated with selective activation of AIT -> DMS projections; other glutamatergic projections to DMS were not activated. AIT-L (but not AIT-M) inactivation or anatomical disconnection of AIT-L -> DMS projections decreased incubated Meth seeking. Unilateral inactivation of AIT-L or D1R blockade of the DMS had no effect on incubated Meth craving, and contralateral disconnection of AIT-L -> DMS projections had no effect on nonincubated Meth seeking. Our results identify a novel role of AIT-L and AIT-L -> DMS glutamatergic projections in incubation of drug craving and drug seeking.
WOS关键词CONTEXT-INDUCED REINSTATEMENT ; PUNISHMENT-IMPOSED ABSTINENCE ; EXTINGUISHED REWARD SEEKING ; COCAINE-SEEKING ; BASOLATERAL AMYGDALA ; PREFRONTAL CORTEX ; DORSAL STRIATUM ; INDUCED RELAPSE ; HEROIN SEEKING ; DRUG-SEEKING
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:000426357200011
资助机构National Institute on Drug Abuse, National Institutes of Health ; China Scholarship Council(201604910135)
源URL[http://ir.psych.ac.cn/handle/311026/25723]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Shaham, Yavin
作者单位1.NIDA, Behav Neurosci Res Branch, Intramural Res Program, NIH, Baltimore, MD 21224 USA
2.Univ Maryland, Dept Psychol, College Pk, MD 20742 USA
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Li, Xuan,Witonsky, Kailyn R.,Lofaro, Olivia M.,et al. Role of Anterior Intralaminar Nuclei of Thalamus Projections to Dorsomedial Striatum in Incubation of Methamphetamine Craving[J]. JOURNAL OF NEUROSCIENCE,2018,38(9):2270-2282.
APA Li, Xuan.,Witonsky, Kailyn R..,Lofaro, Olivia M..,Surjono, Felicia.,Zhang, Jianjun.,...&Shaham, Yavin.(2018).Role of Anterior Intralaminar Nuclei of Thalamus Projections to Dorsomedial Striatum in Incubation of Methamphetamine Craving.JOURNAL OF NEUROSCIENCE,38(9),2270-2282.
MLA Li, Xuan,et al."Role of Anterior Intralaminar Nuclei of Thalamus Projections to Dorsomedial Striatum in Incubation of Methamphetamine Craving".JOURNAL OF NEUROSCIENCE 38.9(2018):2270-2282.

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来源：心理研究所

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