中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Aberrant Functional Connectivity between the Amygdala and the Temporal Pole in DrugFree Generalized Anxiety Disorder

文献类型:期刊论文

作者WeiLi1; HuiruCui1; ZhipeiZhu1; LiKong2; QianGuo1; YikangZhu1; QiangHu3; Lanlan Zhang4; HuiLi1; QingweiLi5
刊名Human Neuroscience
出版日期2016
卷号10期号:0页码:1-9
关键词amygdala DLPFC temporalpole DMN functionalconnectivity generalizedanxietydisorder
英文摘要

The amygdala and the dorsolateral prefrontal cortex (DLPFC) play important roles in “emotion dysregulation,” which has a profound impact on etiologic research of generalized anxiety disorder (GAD). The present study analyzed both eyes-open and eyes-closed resting state functional MRI (rs-fMRI) of 43 subjects (21 GAD patients with medicine free and 22 matched healthy controls). The amygdala and the DLPFC were defined as regions of interest (ROI) to analyze functional connectivity (FC) in GAD patients compared with healthy controls. The main findings revealed GAD patients had increased FC between the amygdala and the temporal pole compared to healthy controls, which was found in both eyes-open and eyes-closed rs-fMRI. And altered FC between the ROIs and brain regions that mainly belonged to the default mode network (DMN) were found. These findings suggest that the abnormal FC between the amygdala and the temporal pole may contribute to the pathophysiology of GAD, and provide insights into the current understanding of the emotion dysregulation of anxiety disorders.

语种英语
源URL[http://ir.psych.ac.cn/handle/311026/22362]  
专题心理研究所_健康与遗传心理学研究室
通讯作者ChunboLi; JijunWang; Zhi Yang
作者单位1.Shanghai KeyLaboratoryofPsychoticDisorders,ShanghaiMentalHealthCenter,ShanghaiJiaoTongUniversitySchoolof Medicine, Shanghai,China
2.CollegeofEducation,ShanghaiNormalUniversity,Shanghai,China
3.Departmentof Psychology,QiqiharMentalHealthCenter,Qiqihar,China,
4.Guangji HospitalofSuzhou,Suzhou,China
5.Departmentof Psychiatry,TongjiHospitalofTongjiUniversity,Shanghai,China,
6.NathanS.KlineInstituteforPsychiatricResearch,New York,NY,USA
7.Shanghai KeyLaboratoryofMagneticResonance,DepartmentofPhysics,EastChinaNormalUniversity, Shanghai, China,
8.Key LaboratoryfortheGeneticsofDevelopmentalandNeuropsychiatricDisorders,Bio-XInstitutes, MinistryofEducation,ShanghaiJiaoTongUniversity,Shanghai,China
9.Brain ScienceandTechnologyResearchCenter, Shanghai JiaoTongUniversity,Shanghai,China, 1
10.CASKeyLaboratoryofBehavioralScienceandMRIResearchCenter, Institute ofPsychology,ChineseAcademyofSciences,Beijing,China
推荐引用方式
GB/T 7714
WeiLi,HuiruCui,ZhipeiZhu,et al. Aberrant Functional Connectivity between the Amygdala and the Temporal Pole in DrugFree Generalized Anxiety Disorder[J]. Human Neuroscience,2016,10(0):1-9.
APA WeiLi.,HuiruCui.,ZhipeiZhu.,LiKong.,QianGuo.,...&Zhi Yang.(2016).Aberrant Functional Connectivity between the Amygdala and the Temporal Pole in DrugFree Generalized Anxiety Disorder.Human Neuroscience,10(0),1-9.
MLA WeiLi,et al."Aberrant Functional Connectivity between the Amygdala and the Temporal Pole in DrugFree Generalized Anxiety Disorder".Human Neuroscience 10.0(2016):1-9.

入库方式: OAI收割

来源:心理研究所

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