Determining the Neural Substrate for Encoding a Memory of Human Pain and the Influence of Anxiety
文献类型：期刊论文
| 作者 | Tseng, Ming-Tsung1,2,3; Kong, Yazhuo2,3,4,5 ; Eippert, Falk2,3; Tracey, Irene2,3
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| 刊名 | JOURNAL OF NEUROSCIENCE
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| 出版日期 | 2017-12-06 |
| 卷号 | 37期号:49页码:11806-11817 |
| 关键词 | cognition encoding fMRI pain sensation vibration |
| ISSN号 | 0270-6474 |
| DOI | 10.1523/JNEUROSCI.0750-17.2017 |
| 文献子类 | Article |
| 英文摘要 | To convert a painful stimulus into a briefly maintainable construct when the painful stimulus is no longer accessible is essential to guide human behavior and avoid dangerous situations. Because of the aversive nature of pain, this encoding process might be influenced by emotional aspects and could thus vary across individuals, but we have yet to understand both the basic underlying neural mechanisms as well as potential interindividual differences. Using fMRI in combination with a delayed-discrimination task in healthy volunteers of both sexes, we discovered that brain regions involved in this working memory encoding process were dissociable according to whether the to-be-remembered stimulus was painful or not, with the medial thalamus and the rostral anterior cingulate cortex encoding painful and the primary somatosensory cortex encoding nonpainful stimuli. Encoding of painful stimuli furthermore significantly enhanced functional connectivity between the thalamus and medial prefrontal cortex (mPFC). With regards to emotional aspects influencing encoding processes, we observed that more anxious participants showed significant performance advantages when encoding painful stimuli. Importantly, only during the encoding of pain, the interindividual differences in anxiety were associated with the strength of coupling between medial thalamus and mPFC, which was furthermore related to activity in the amygdala. These results indicate not only that there is a distinct signature for the encoding of a painful experience in humans, but also that this encoding process involves a strong affective component. |
| WOS关键词 | MEDIAL PREFRONTAL CORTEX ; PRIMARY SOMATOSENSORY CORTEX ; WORKING-MEMORY ; FUNCTIONAL CONNECTIVITY ; HUMAN BRAIN ; STIMULATION ; PERCEPTION ; ATTENTION ; DISCRIMINATION ; THALAMUS |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000418053700005 |
| 资助机构 | National Science Council(100-2917-I-564-028) ; Ministry of Science and Technology(103-2410-H-002-121-MY2) ; National Health Research Institutes of Taiwan(NHRI-EX106-10615NC) ; Marie Curie Fellowship(273805) ; National Institute for Health Research Oxford Biomedical Research Centre ; Medical Research Council of Great Britain and Northern Ireland ; Wellcome Trust (London, UK) |
| 源URL | [http://ir.psych.ac.cn/handle/311026/25628]  |
| 专题 | 心理研究所_健康与遗传心理学研究室 |
| 作者单位 | 1.Natl Taiwan Univ, Grad Inst Brain & Mind Sci, Coll Med, 1 Jen Rd Sect 1, Taipei 10051, Taiwan 2.Univ Oxford, Oxford Ctr Funct Magnet Resonance Imaging Brain, Oxford OX3 9DU, England 3.Univ Oxford, Nuffield Div Anaesthet, Nuffield Dept Clin Neurosci, Oxford OX3 9DU, England 4.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tseng, Ming-Tsung,Kong, Yazhuo,Eippert, Falk,et al. Determining the Neural Substrate for Encoding a Memory of Human Pain and the Influence of Anxiety[J]. JOURNAL OF NEUROSCIENCE,2017,37(49):11806-11817. |
| APA | Tseng, Ming-Tsung,Kong, Yazhuo,Eippert, Falk,&Tracey, Irene.(2017).Determining the Neural Substrate for Encoding a Memory of Human Pain and the Influence of Anxiety.JOURNAL OF NEUROSCIENCE,37(49),11806-11817. |
| MLA | Tseng, Ming-Tsung,et al."Determining the Neural Substrate for Encoding a Memory of Human Pain and the Influence of Anxiety".JOURNAL OF NEUROSCIENCE 37.49(2017):11806-11817. |
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来源：心理研究所
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