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Impaired Functional Criticality of Human Brain during Alzheimer's Disease Progression

文献类型：期刊论文

作者Jiang, Lili1,2,3; Sui, Danyang1,2,4; Qiao, Kaini1,2,4; Dong, Hao-Ming1,2,4; Chen, Luonan5; Han, Ying6,7,8,9,10,11; Jiang Lili; Han Ying
刊名SCIENTIFIC REPORTS
出版日期2018-01-22
卷号8期号:1页码:doi: 10. 1038/s41598-018-19674-7
ISSN号2045-2322
DOI10.1038/s41598-018-19674-7
产权排序1
文献子类Article
英文摘要The progression of Alzheimer's Disease (AD) has been proposed to comprise three stages, subjective cognitive decline (SCD), mild cognitive impairment (MCI), and AD. Was brain dynamics across the three stages smooth? Was there a critical transition? How could we characterize and study functional criticality of human brain? Based on dynamical characteristics of critical transition from nonlinear dynamics, we proposed a vertex-wise Index of Functional Criticality (vIFC) of fMRI time series in this study. Using 42 SCD, 67 amnestic MCI (aMCI), 34 AD patients as well as their age-, sex-, years of education-matched 54 NC, our new method vIFC successfully detected significant patient-normal differences for SCD and aMCI, as well as significant negative correlates of vIFC in the right middle temporal gyrus with total scores of Montreal Cognitive Assessment (MoCA) in SCD. In comparison, standard deviation of fMRI time series only detected significant differences between AD patients and normal controls. As an index of functional criticality of human brain derived from nonlinear dynamics, vIFC could serve as a sensitive neuroimaging marker for future studies; considering much more vIFC impairments in aMCI compared to SCD and AD, our study indicated aMCI as a critical stage across AD progression.
WOS关键词MILD COGNITIVE IMPAIRMENT ; SUBJECTIVE MEMORY IMPAIRMENT ; SURFACE-BASED ANALYSIS ; DECLINE ; BIOMARKERS ; CORTEX ; CONNECTIVITY ; TASK
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000422912100007
资助机构National Natural Science Foundation of China(11674388 ; Startup Foundation for Young Talents of the Institute of Psychology(Y1CX222005) ; National Key Basic Research and Development (973) Program(2015CB351702) ; National Key Research and Development Program of China(2016YFC1306300) ; Beijing Nature Science Foundation(7161009) ; Beijing Municipal Science & Technology Commission(Z161100002616020) ; Capital Medical University(16JL-L08) ; 11204369 ; 81471740 ; 31371007 ; 81430037 ; 61633018)
源URL[http://ir.psych.ac.cn/handle/311026/25700]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Jiang Lili; Han Ying
作者单位1.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Lifespan Connect & Behav Team, Beijing 100101, Peoples R China
3.Princeton Univ, Princeton Neurosci Inst, Princeton, NJ 08544 USA
4.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Biol Sci, Innovat Ctr Cell Signaling Network, Inst Biochem & Cell Biol,Key Lab Syst Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China
6.Capital Med Univ, XuanWu Hosp, Dept Neurol, Beijing 100053, Peoples R China
7.Ctr Alzheimers Dis, Beijing 100053, Peoples R China
8.Inst Brain Disorders, Beijing 100053, Peoples R China
9.Beijing Inst Geriatr, Beijing 100053, Peoples R China
10.Natl Clin Res Ctr Geriatr Disorders, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Jiang, Lili,Sui, Danyang,Qiao, Kaini,et al. Impaired Functional Criticality of Human Brain during Alzheimer's Disease Progression[J]. SCIENTIFIC REPORTS,2018,8(1):doi: 10. 1038/s41598-018-19674-7.
APA Jiang, Lili.,Sui, Danyang.,Qiao, Kaini.,Dong, Hao-Ming.,Chen, Luonan.,...&Han Ying.(2018).Impaired Functional Criticality of Human Brain during Alzheimer's Disease Progression.SCIENTIFIC REPORTS,8(1),doi: 10. 1038/s41598-018-19674-7.
MLA Jiang, Lili,et al."Impaired Functional Criticality of Human Brain during Alzheimer's Disease Progression".SCIENTIFIC REPORTS 8.1(2018):doi: 10. 1038/s41598-018-19674-7.

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来源：心理研究所

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