Killing of Staphylococcus aureus via Magnetic Hyperthermia Mediated by Magnetotactic Bacteria
文献类型：期刊论文
| 作者 | Chen, Changyou1,2,3; Chen, Linjie1,2,3; Yi, Yong4; Chen, Chuanfang1,3; Wu, Long-Fei3,5; Song, Tao1,3 |
| 刊名 | APPLIED AND ENVIRONMENTAL MICROBIOLOGY
 |
| 出版日期 | 2016-04-01 |
| 卷号 | 82期号:7页码:2219-2226 |
| ISSN号 | 0099-2240 |
| DOI | 10.1128/AEM.04103-15 |
| 文献子类 | Article |
| 英文摘要 | Staphylococcus aureus is a common hospital and household pathogen. Given the emergence of antibiotic-resistant derivatives of this pathogen resulting from the use of antibiotics as general treatment, development of alternative therapeutic strategies is urgently needed. Here, we assess the feasibility of killing S. aureus cells in vitro and in vivo through magnetic hyperthermia mediated by magnetotactic bacteria that possess magnetic nanocrystals and demonstrate magnetically steered swimming. The S. aureus suspension was added to magnetotactic MO-1 bacteria either directly or after coating with anti-MO-1 polyclonal antibodies. The suspensions were then subjected to an alternating magnetic field (AMF) for 1 h. S. aureus viability was subsequently assessed through conventional plate counting and flow cytometry. We found that approximately 30% of the S. aureus cells mixed with uncoated MO-1 cells were killed after AMF treatment. Moreover, attachment between the magnetotactic bacteria and S. aureus increased the killing efficiency of hyperthermia to more than 50%. Using mouse models, we demonstrated that magnetic hyperthermia mediated by antibody-coated magnetotactic MO-1 bacteria significantly improved wound healing. These results collectively demonstrated the effective eradication of S. aureus both in vitro and in vivo, indicating the potential of magnetotactic bacterium-mediated magnetic hyperthermia as a treatment for S. aureus-induced skin or wound infections. |
| WOS关键词 | IRON-OXIDE NANOPARTICLES ; ION CHANNELS ; MAGNETOSOMES ; INFECTION ; BEHAVIOR ; CANCER ; SKIN |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000373342400025 |
| 出版者 | AMER SOC MICROBIOLOGY |
| 资助机构 | LIA-BioMNSL from Centre National de la Recherche Scientifique ; LIA-BioMNSL from Centre National de la Recherche Scientifique ; State Key Programme of National Natural Science of China(51037006) ; State Key Programme of National Natural Science of China(51037006) ; LIA-BioMNSL from Centre National de la Recherche Scientifique ; LIA-BioMNSL from Centre National de la Recherche Scientifique ; State Key Programme of National Natural Science of China(51037006) ; State Key Programme of National Natural Science of China(51037006) ; LIA-BioMNSL from Centre National de la Recherche Scientifique ; LIA-BioMNSL from Centre National de la Recherche Scientifique ; State Key Programme of National Natural Science of China(51037006) ; State Key Programme of National Natural Science of China(51037006) ; LIA-BioMNSL from Centre National de la Recherche Scientifique ; LIA-BioMNSL from Centre National de la Recherche Scientifique ; State Key Programme of National Natural Science of China(51037006) ; State Key Programme of National Natural Science of China(51037006) |
| 源URL | [http://ir.iggcas.ac.cn/handle/132A11/79864]  |
| 专题 | 中国科学院地质与地球物理研究所 |
| 通讯作者 | Wu, Long-Fei; Song, Tao |
| 作者单位 | 1.Chinese Acad Sci, Inst Elect Engn, Beijing Key Lab Bioelectromagnetism, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.France China Biomineralizat & Nanostruct Lab, Beijing, Peoples R China 4.306 Hosp PLA, Beijing, Peoples R China 5.Aix Marseille Univ, Lab Chim Bacterienne, UMR7283, Inst Microbiol Mediterranee,CNRS, Marseille, France |
| 推荐引用方式 GB/T 7714 | Chen, Changyou,Chen, Linjie,Yi, Yong,et al. Killing of Staphylococcus aureus via Magnetic Hyperthermia Mediated by Magnetotactic Bacteria[J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY,2016,82(7):2219-2226. |
| APA | Chen, Changyou,Chen, Linjie,Yi, Yong,Chen, Chuanfang,Wu, Long-Fei,&Song, Tao.(2016).Killing of Staphylococcus aureus via Magnetic Hyperthermia Mediated by Magnetotactic Bacteria.APPLIED AND ENVIRONMENTAL MICROBIOLOGY,82(7),2219-2226. |
| MLA | Chen, Changyou,et al."Killing of Staphylococcus aureus via Magnetic Hyperthermia Mediated by Magnetotactic Bacteria".APPLIED AND ENVIRONMENTAL MICROBIOLOGY 82.7(2016):2219-2226. |
入库方式： OAI收割
来源：地质与地球物理研究所
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