中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 地质与地球物理研究所
  3. 中国科学院地质与地球物理研究所
Construction and operation of a microrobot based on magnetotactic bacteria in a microfluidic chip

文献类型：期刊论文

作者Ma, Qiufeng1,2,3; Chen, Changyou1,2,3; Wei, Shufeng1,2,3; Chen, Chuanfang1,2,3; Wu, Long-Fei3,4; Song, Tao1,3
刊名BIOMICROFLUIDICS
出版日期2012-06-01
卷号6期号:2
ISSN号1932-1058
DOI10.1063/1.3702444
文献子类Article
英文摘要Magnetotactic bacteria (MTB) are capable of swimming along magnetic field lines. This unique feature renders them suitable in the development of magnetic-guided, auto-propelled microrobots to serve in target molecule separation and detection, drug delivery, or target cell screening in a microfluidic chip. The biotechnology to couple these bacteria with functional loads to form microrobots is the critical point in its application. Although an immunoreaction approach to attach functional loads to intact MTB was suggested, details on its realization were hardly mentioned. In the current paper, MTB-microrobots were constructed by attaching 2 mu m diameter microbeads to marine magnetotactic ovoid MO-1 cells through immunoreactions. These microrobots were controlled using a special control and tracking system. Experimental results prove that the attachment efficiency can be improved to similar to 30% via an immunoreaction. The motility of the bacteria attached with different number of loads was also assessed. The results show that MTB can transport one load at a velocity of similar to 21 mu m/s and still move and survive for over 30 min. The control and tracking system is fully capable of directing and monitoring the movement of the MTB-microrobots. The rotating magnetic fields can stop the microrobots by trapping them as they swim within a circular field with a controllable size. The system has potential use in chemical analyses and medical diagnoses using biochips as well as in nano/microscale transport. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.3702444]
WOS关键词SYSTEMS ; NANOPARTICLES ; MANIPULATION ; MOTORS ; ESTERS ; PDMS
WOS研究方向Biochemistry & Molecular Biology ; Biophysics ; Science & Technology - Other Topics ; Physics
语种英语
WOS记录号WOS:000305839800018
出版者AMER INST PHYSICS
资助机构State Key Program of National Natural Science of China(51037006) ; State Key Program of National Natural Science of China(51037006) ; State Key Program of National Natural Science of China(51037006) ; State Key Program of National Natural Science of China(51037006) ; State Key Program of National Natural Science of China(51037006) ; State Key Program of National Natural Science of China(51037006) ; State Key Program of National Natural Science of China(51037006) ; State Key Program of National Natural Science of China(51037006)
源URL[http://ir.iggcas.ac.cn/handle/132A11/84178]  
专题中国科学院地质与地球物理研究所
通讯作者Ma, Qiufeng
作者单位1.Chinese Acad Sci, Beijing Key Lab Bioelectromagnetism, Inst Elect Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.France China Biomineralizat & Nanostruct Lab, Beijing 100193, Peoples R China
4.Univ Aix Marseille 2, Inst Microbiol Mediterranee, CNRS, Lab Chim Bacterienne,UPR9043, F-13402 Marseille 20, France
推荐引用方式
GB/T 7714		 Ma, Qiufeng,Chen, Changyou,Wei, Shufeng,et al. Construction and operation of a microrobot based on magnetotactic bacteria in a microfluidic chip[J]. BIOMICROFLUIDICS,2012,6(2).
APA Ma, Qiufeng,Chen, Changyou,Wei, Shufeng,Chen, Chuanfang,Wu, Long-Fei,&Song, Tao.(2012).Construction and operation of a microrobot based on magnetotactic bacteria in a microfluidic chip.BIOMICROFLUIDICS,6(2).
MLA Ma, Qiufeng,et al."Construction and operation of a microrobot based on magnetotactic bacteria in a microfluidic chip".BIOMICROFLUIDICS 6.2(2012).

入库方式： OAI收割

来源：地质与地球物理研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。