Enhanced peroxidase activity and tumour tissue visualization by cobalt-doped magnetoferritin nanoparticles
文献类型：期刊论文
| 作者 | Zhang, Tongwei1,2; Cao, Changqian1,2; Tang, Xu3; Cai, Yao1,2,4; Yang, Caiyun1,2,4; Pan, Yongxin1,2,3 |
| 刊名 | NANOTECHNOLOGY
 |
| 出版日期 | 2017-01-27 |
| 卷号 | 28期号:4 |
| 关键词 | Magnetoferritin Peroxidase-like Activity Kinetic Analysis Visualizing Tumour Tissues Cobalt-doping |
| ISSN号 | 0957-4484 |
| DOI | 10.1088/1361-6528/28/4/045704 |
| 文献子类 | Article |
| 英文摘要 | Magnetoferritin (M-HFn) is a biomimetic magnetic nanoparticle with a human heavy-chain ferritin (HFn) shell, trapping a magnetite (Fe3O4) core that has inherited peroxidase-like activity. In this study, cobalt-doped M-HFn nanoparticles (M-HFn-CoxFe3-xO4) with different amounts of cobalt were successfully synthesized. Experimental results indicate that the controlled doping of a certain amount of cobalt into the magnetite cores of M-HFn nanoparticles enhances its peroxidase-like catalytic activity and efficacy for visualizing tumour tissues. For example, compared with sample Co0 (without cobalt doping), the peroxidase-like activity of the cobalt-doped nanoparticle sample Co60 (with a cobalt doping molar percentage of similar to 34.2%) increases 1.7 times, and has the maximal reaction velocity (V-max) values. Moreover, after a one-step incubation with Co60 nanoparticles, and using the peroxidase substrate 3,3'-diaminobenzidine tetrahydrochloride (DAB) for colour development, the tumour tissues of breast, colorectal, stomach and pancreas tumours showed a deeper brown colour with clear boundaries between the healthy and tumourous cells. Therefore, this suggests that the cobalt-doped magnetoferritin nanoparticles enhance peroxidase activity and tumour tissue visualization. |
| WOS关键词 | CANCER-CELLS ; IRON-OXIDE ; FERRITIN ; GLUCOSE ; MIMETICS ; PROTEIN ; SIZE ; CAGE |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000391569300003 |
| 出版者 | IOP PUBLISHING LTD |
| 资助机构 | CAS Key Research Program of Frontier Sciences ; National Natural Science Foundation of China(41330104 ; National R&D Projects for Key Scientific Instruments(ZDYZ2012-1-01-02) ; 41574062 ; 41621004) ; CAS Key Research Program of Frontier Sciences ; National Natural Science Foundation of China(41330104 ; National R&D Projects for Key Scientific Instruments(ZDYZ2012-1-01-02) ; 41574062 ; 41621004) ; CAS Key Research Program of Frontier Sciences ; National Natural Science Foundation of China(41330104 ; National R&D Projects for Key Scientific Instruments(ZDYZ2012-1-01-02) ; 41574062 ; 41621004) ; CAS Key Research Program of Frontier Sciences ; National Natural Science Foundation of China(41330104 ; National R&D Projects for Key Scientific Instruments(ZDYZ2012-1-01-02) ; 41574062 ; 41621004) |
| 源URL | [http://ir.iggcas.ac.cn/handle/132A11/53157]  |
| 专题 | 地质与地球物理研究所_中国科学院地球与行星物理重点实验室 |
| 通讯作者 | Pan, Yongxin |
| 作者单位 | 1.Chinese Acad Sci, Inst Geol & Geophys, Paleomagnetism & Geochronol Lab, Key Lab Earth & Planetary Phys, Beijing 100029, Peoples R China 2.Chinese Acad Sci, Inst Geol & Geophys, France China Biomineralizat & Nanostruct Lab, Beijing 100029, Peoples R China 3.Chinese Acad Sci, Inst Geol & Geophys, Electron Microscope Lab, Beijing 100029, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Tongwei,Cao, Changqian,Tang, Xu,et al. Enhanced peroxidase activity and tumour tissue visualization by cobalt-doped magnetoferritin nanoparticles[J]. NANOTECHNOLOGY,2017,28(4). |
| APA | Zhang, Tongwei,Cao, Changqian,Tang, Xu,Cai, Yao,Yang, Caiyun,&Pan, Yongxin.(2017).Enhanced peroxidase activity and tumour tissue visualization by cobalt-doped magnetoferritin nanoparticles.NANOTECHNOLOGY,28(4). |
| MLA | Zhang, Tongwei,et al."Enhanced peroxidase activity and tumour tissue visualization by cobalt-doped magnetoferritin nanoparticles".NANOTECHNOLOGY 28.4(2017). |
入库方式： OAI收割
来源：地质与地球物理研究所
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