Cytotoxicity and genotoxicity of bacterial magnetosomes against human retinal pigment epithelium cells
文献类型：期刊论文
| 作者 | Qi, Lei1; Lv, Xiujuan1; Zhang, Tongwei2,3; Jia, Peina1; Yan, Ruiying1; Li, Shuli4; Zou, Ruitao1; Xue, Yuhua1; Dai, Liming1,5 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016-06-01 |
| 卷号 | 6 |
| DOI | 10.1038/srep26961 |
| 文献子类 | Article |
| 英文摘要 | A variety of nanomaterials have been developed for ocular diseases. The ability of these nanomaterials to pass through the blood-ocular barrier and their biocompatibility are essential characteristics that must be considered. Bacterial magnetosomes (BMs) are a type of biogenic magnetic nanomaterials synthesized by magnetotactic bacteria. Due to their unique biomolecular membrane shell and narrow size distribution of approximately 30 nm, BMs can pass through the blood-brain barrier. The similarity of the blood-ocular barrier to the blood-brain barrier suggests that BMs have great potential as treatments for ocular diseases. In this work, BMs were isolated from magnetotactic bacteria and evaluated in various cytotoxicity and genotoxicity studies in human retinal pigment epithelium (ARPE-19) cells. The BMs entered ARPE-19 cells by endocytosis after a 6-h incubation and displayed much lower cytotoxicity than chemically synthesized magnetic nanoparticles (MNPs). MNPs exhibited significantly higher genotoxicity than BMs and promoted the expression of Bax (the programmed cell death acceleration protein) and the induction of greater cell necrosis. In BM-treated cells, apoptosis tended to be suppressed via increased expression of the Bcl-2 protein. In conclusion, BMs display excellent biocompatibility and potential for use in the treatment of ocular diseases. |
| WOS关键词 | MAGNETOSPIRILLUM-GRYPHISWALDENSE MSR-1 ; MAGNETIC NANOPARTICLES ; MAGNETOTACTIC BACTERIA ; IN-VIVO ; BIOCOMPATIBILITY ; BCL-2 |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000377157600001 |
| 资助机构 | Zhejiang National Nature Science Foundation(LQ14C100002) ; Zhejiang National Nature Science Foundation(LQ14C100002) ; National Natural Science Foundation of China(51202167 ; National Natural Science Foundation of China(51202167 ; National "Thousand Talents Program" ; National "Thousand Talents Program" ; Case Western Reserve University-Wenzhou Medical University(CON115346) ; Case Western Reserve University-Wenzhou Medical University(CON115346) ; Wenzhou Bureau of Science and Technology(2013S0458) ; Wenzhou Bureau of Science and Technology(2013S0458) ; 21405115) ; 21405115) ; Zhejiang National Nature Science Foundation(LQ14C100002) ; Zhejiang National Nature Science Foundation(LQ14C100002) ; National Natural Science Foundation of China(51202167 ; National Natural Science Foundation of China(51202167 ; National "Thousand Talents Program" ; National "Thousand Talents Program" ; Case Western Reserve University-Wenzhou Medical University(CON115346) ; Case Western Reserve University-Wenzhou Medical University(CON115346) ; Wenzhou Bureau of Science and Technology(2013S0458) ; Wenzhou Bureau of Science and Technology(2013S0458) ; 21405115) ; 21405115) |
| 源URL | [http://ir.iggcas.ac.cn/handle/132A11/53436]  |
| 专题 | 地质与地球物理研究所_中国科学院地球与行星物理重点实验室 |
| 作者单位 | 1.Wenzhou Med Univ, Inst Adv Mat Nanobio Applicat, Sch Ophthalmol & Optometry, Hosp Eye, 270 Xueyuan Xi Rd, Wenzhou 325027, Zhejiang, Peoples R China 2.Chinese Acad Sci, Inst Geol & Geophys, Key Lab Earth & Planetary Phys, Biogeomagnetism Grp,Paleomagnetism & Geochronol L, Beijing 100029, Peoples R China 3.Chinese Acad Sci, France China Biomineralizat & Nanostruct Lab, Beijing 100029, Peoples R China 4.China Agr Univ, Dept Microbiol, Coll Biol Sci, Beijing 100193, Peoples R China 5.Case Western Reserve Univ, Dept Macromol Sci & Engn, Ctr Adv Sci & Engn Carbon Case4Carbon, Cleveland, OH 44106 USA |
| 推荐引用方式 GB/T 7714 | Qi, Lei,Lv, Xiujuan,Zhang, Tongwei,et al. Cytotoxicity and genotoxicity of bacterial magnetosomes against human retinal pigment epithelium cells[J]. SCIENTIFIC REPORTS,2016,6. |
| APA | Qi, Lei.,Lv, Xiujuan.,Zhang, Tongwei.,Jia, Peina.,Yan, Ruiying.,...&Dai, Liming.(2016).Cytotoxicity and genotoxicity of bacterial magnetosomes against human retinal pigment epithelium cells.SCIENTIFIC REPORTS,6. |
| MLA | Qi, Lei,et al."Cytotoxicity and genotoxicity of bacterial magnetosomes against human retinal pigment epithelium cells".SCIENTIFIC REPORTS 6(2016). |
入库方式： OAI收割
来源：地质与地球物理研究所
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